GSK-1562590

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576009

CAS#: 1003877-55-1

Description: GSK-1562590 is a urotensin-II receptor antagonist.

Chemical Structure

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GSK-1562590
CAS# 1003877-55-1
Instruction

Theoretical Analysis

MedKoo Cat#: 576009
Name: GSK-1562590
CAS#: 1003877-55-1
Chemical Formula: C30H30Cl2N4O4
Exact Mass: 580.16
Molecular Weight: 581.490
Elemental Analysis: C, 61.97; H, 5.20; Cl, 12.19; N, 9.64; O, 11.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GSK 1562590; GSK1562590; GSK-1562590

IUPAC/Chemical Name: 4H-1,4-Benzoxazine-4-acetamide, N-((1R)-1-(3'-(aminocarbonyl)(1,1'-biphenyl)-4-yl)-2-(1-pyrrolidinyl)ethyl)-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-

InChi Key: QDUMEBKFKOODFN-SANMLTNESA-N

InChi Code: InChI=1S/C30H30Cl2N4O4/c1-34(28(37)17-36-25-14-23(31)24(32)15-27(25)40-18-29(36)38)26(16-35-11-2-3-12-35)20-9-7-19(8-10-20)21-5-4-6-22(13-21)30(33)39/h4-10,13-15,26H,2-3,11-12,16-18H2,1H3,(H2,33,39)/t26-/m0/s1

SMILES Code: CN([C@@H](CN1CCCC1)c2ccc(cc2)c3cccc(c3)C(=O)N)C(=O)CN4C(=O)COc5cc(Cl)c(Cl)cc45

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 581.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Behm DJ, Aiyar NV, Olzinski AR, McAtee JJ, Hilfiker MA, Dodson JW, Dowdell SE, Wang GZ, Goodman KB, Sehon CA, Harpel MR, Willette RN, Neeb MJ, Leach CA, Douglas SA. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br J Pharmacol. 2010 Sep;161(1):207-28. doi: 10.1111/j.1476-5381.2010.00889.x. PMID: 20718751; PMCID: PMC2962828.