Lodaxaprine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413207

CAS#: 93181-81-8

Description: Lodaxaprine is an anticonvulsant agent

Chemical Structure

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Lodaxaprine
CAS# 93181-81-8
Instruction

Theoretical Analysis

MedKoo Cat#: 413207
Name: Lodaxaprine
CAS#: 93181-81-8
Chemical Formula: C15H16ClN3O
Exact Mass: 289.10
Molecular Weight: 289.760
Elemental Analysis: C, 62.18; H, 5.57; Cl, 12.23; N, 14.50; O, 5.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lodaxaprine; CM40907; CM-40907; CM 40907

IUPAC/Chemical Name: 1-(6-(o-Chlorophenyl)-3-pyridazinyl)-4-piperidinol

InChi Key: USEZRIFSJXAMJD-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16ClN3O/c16-13-4-2-1-3-12(13)14-5-6-15(18-17-14)19-9-7-11(20)8-10-19/h1-6,11,20H,7-10H2

SMILES Code: OC1CCN(C2=NN=C(C3=CC=CC=C3Cl)C=C2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 289.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chambon JP, Brochard J, Hallot A, Heaulme M, Brodin R, Roncucci R, Biziere K. CM 40907: a structurally novel anticonvulsant in mice, rats and baboons. J Pharmacol Exp Ther. 1985 Jun;233(3):836-44. PMID: 2989499.

2: Stanková L, Mares P. Antimetrazol action of two potential anticonvulsants, CM 40907 and SR 41378, in immature rats. Physiol Res. 1992;41(6):451-7. PMID: 1299328.

3: Schaffler K, Wauschkuhn CH, Gierend M. Analgesic potency of a new anticonvulsant drug versus acetylsalicylic acid via laser somatosensory evoked potentials. Randomized placebo-controlled double-blind (5-way) crossover study. Arzneimittelforschung. 1991 Apr;41(4):427-35. PMID: 1859518.

4: Perio A, Chambon JP, Calassi R, Heaulme M, Biziere K. Evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats. J Pharmacol Exp Ther. 1986 Nov;239(2):542-7. PMID: 3095540.

5: Yepez-Lasso R, Duncan JS, Shorvon SD. Suppression of inter-ictal spikes by CM40907. A double-blind placebo-controlled investigation and review of spike counting as a methodology for assessing the antiepileptic effect of drugs. Epilepsy Res. 1990 Apr;5(3):247-50. doi: 10.1016/0920-1211(90)90046-x. PMID: 2384080.