Chlorisondamine chloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413174

CAS#: 69-27-2

Description: Chlorisondamine chloride is a nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.

Chemical Structure

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Chlorisondamine chloride
CAS# 69-27-2
Instruction

Theoretical Analysis

MedKoo Cat#: 413174
Name: Chlorisondamine chloride
CAS#: 69-27-2
Chemical Formula: C14H20Cl6N2
Exact Mass: 425.98
Molecular Weight: 429.030
Elemental Analysis: C, 39.19; H, 4.70; Cl, 49.58; N, 6.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Chlorisondamine chloride; SU3088; SU-3088; SU 3088

IUPAC/Chemical Name: 1H-Isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride

InChi Key: DXXUGBPKQDTBQW-UHFFFAOYSA-L

InChi Code: InChI=1S/C14H20Cl4N2.2ClH/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2

SMILES Code: C[N+](CC[N+]1(C)CC2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C1)(C)C.[Cl-].[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Marenco T, Bernstein S, Cumming P, Clarke PB. Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats. Br J Pharmacol. 2000 Jan;129(1):147-55. doi: 10.1038/sj.bjp.0703005. PMID: 10694214; PMCID: PMC1621125.

2: Chadman KK, Woods JH, Stitzel J. Chlorisondamine inhibits the nicotine- induced stimulation of c-fos in the pigeon brain for up to 2 weeks. Nicotine Tob Res. 2007 Sep;9(9):927-36. doi: 10.1080/14622200701540838. PMID: 17763108.

3: Chadman KK, Woods JH. Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon. J Pharmacol Exp Ther. 2004 Jan;308(1):73-8. doi: 10.1124/jpet.103.057307. Epub 2003 Oct 17. PMID: 14566012.

4: Clarke PB, Chaudieu I, el-Bizri H, Boksa P, Quik M, Esplin BA, Capek R. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111(2):397-405. doi: 10.1111/j.1476-5381.1994.tb14748.x. PMID: 7911713; PMCID: PMC1909961.

5: el-Bizri H, Clarke PB. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine administered in vivo. Br J Pharmacol. 1994 Feb;111(2):414-8. doi: 10.1111/j.1476-5381.1994.tb14750.x. PMID: 8004385; PMCID: PMC1909959.

6: el-Bizri H, Clarke PB. Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br J Pharmacol. 1994 Nov;113(3):917-25. doi: 10.1111/j.1476-5381.1994.tb17080.x. PMID: 7858886; PMCID: PMC1510460.

7: Gatineau E, Gong MC, Yiannikouris F. Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice. Hypertension. 2019 Oct;74(4):1014-1020. doi: 10.1161/HYPERTENSIONAHA.119.12906. Epub 2019 Aug 5. PMID: 31378099; PMCID: PMC6739191.

8: Woods AS, Moyer SC, Wang HY, Wise RA. Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor. J Proteome Res. 2003 Mar- Apr;2(2):207-12. doi: 10.1021/pr025578h. PMID: 12716135.

9: CHIRONE E. L'IPERTENSIONE MALIGNA [MALIGNANT HYPERTENSION]. Policlinico Prat. 1964 Mar 2;71:325-38. Italian. PMID: 14143292.

10: Chaouloff F, Baudrie V, Coupry I. Effects of chlorisondamine and restraint on cortical [3H]ketanserin binding, 5-HT2A receptor-mediated head shakes, and behaviours in models of anxiety. Neuropharmacology. 1994 Mar-Apr;33(3-4):449-56. doi: 10.1016/0028-3908(94)90075-2. PMID: 7984283.