KDI-792 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575475

CAS#: 130047-30-2

Description: KDI-792 hydrochloride is a thromboxane dual blocker.

Chemical Structure

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KDI-792 hydrochloride
CAS# 130047-30-2
Instruction

Theoretical Analysis

MedKoo Cat#: 575475
Name: KDI-792 hydrochloride
CAS#: 130047-30-2
Chemical Formula: C22H27Cl2N3O4S
Exact Mass: 499.11
Molecular Weight: 500.430
Elemental Analysis: C, 52.80; H, 5.44; Cl, 14.17; N, 8.40; O, 12.79; S, 6.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FK 070; FK-070; FK070; KDI 792; KDI792; KDI-792 HCl; KDI-792 hydrochloride

IUPAC/Chemical Name: 5-Hexenoic acid, 6-((2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1-(3- pyridinylmethyl)-2-pyrrolidinyl)-, monohydrochloride, (5Z)-

InChi Key: JGCFJVFIRFTRKJ-YOLZMAEBSA-N

InChi Code: InChI=1S/C22H26ClN3O4S.ClH/c23-18-8-10-21(11-9-18)31(29,30)25-19-13-20(6-2-1-3-7-22(27)28)26(16-19)15-17-5-4-12-24-14-17;/h2,4-6,8-12,14,19-20,25H,1,3,7,13,15-16H2,(H,27,28);1H/b6-2-;/t19-,20-;/m1./s1

SMILES Code: Cl.OC(=O)CCC\C=C/[C@@H]1C[C@H](CN1Cc2cccnc2)NS(=O)(=O)c3ccc(Cl)cc3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 500.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Sone H, Okuda Y, Tsurushima Y, Asano M, Suzuki S, Kawakami Y, Yamashita K. Acute effects of thromboxane dual blocker (KDI-792) on different portions of lower limb blood flow--a study using Doppler ultrasonography and laser Doppler flowmetry in type 2 diabetic patients. Prostaglandins. 1997 Jun;53(6):395-409. doi: 10.1016/s0090-6980(97)00057-9. PMID: 9261860.

2. Ono Y, Katoh M, Hirayama A, Koike T. Improvement in blood flow and diabetic neuropathy by thromboxane A2 dual blocker KDI-792. Prostaglandins Leukot Essent Fatty Acids. 1995 Aug;53(2):139-45. doi: 10.1016/0952-3278(95)90141-8. PMID: 7480076.

3. Uematsu T, Kosuge K, Umemura K, Nakano M, Terakawa M, Nakashima M. Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. J Pharm Pharmacol. 1996 Apr;48(4):380-5. doi: 10.1111/j.2042-7158.1996.tb05937.x. PMID: 8794987.

4. Sone H, Okuda Y, Kawakami Y, Yamashita K. Effects of high glucose concentration and a thromboxane synthase inhibitor on the production of thromboxane A2 and prostaglandin I2 and E2 by retinal endothelial cells. Life Sci. 1996;58(3):239-43. doi: 10.1016/0024-3205(95)02281-3. PMID: 9499164.