SET2
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463662

CAS#: 2313525-20-9

Description: SET2 is a novel selective TRPV2 antagonist.

Chemical Structure

img
SET2
CAS# 2313525-20-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 463662
Name: SET2
CAS#: 2313525-20-9
Chemical Formula: C17H21F3N4O2S
Exact Mass: 402.13
Molecular Weight: 402.440
Elemental Analysis: C, 50.74; H, 5.26; F, 14.16; N, 13.92; O, 7.95; S, 7.97

Price and Availability

Size Price Availability Quantity
25mg USD -2 2 Weeks
100mg USD -2 2 Weeks
200mg USD -2 2 Weeks
500mg USD -2 2 Weeks
1g USD -2 2 Weeks
2g USD -2 2 Weeks
5g USD -2 2 Weeks
10mg USD 340 2 Weeks
50mg USD 960 2 Weeks
Bulk inquiry

Synonym: SET2; SET 2; SET-2;

IUPAC/Chemical Name: N-(furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide

InChi Key: LZHSWRWIMQRTOP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)

SMILES Code: FC(F)(F)C1=CC(N(C)CCC)=NC(SCCC(NCC2=CC=CO2)=O)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: SET2 is a selective TRPV2 antagonist (IC50=0.46 μM).
In vitro activity: This study describes the discovery of SET2, which was then employed as a chemical probe. SET2 inhibited TRPV2, which reduced prostate cancer migration, highlighting TRPV2 as a potential antimetastasis therapeutic target. Functional assays indicated the coupling of TRPV2 to the metastasis mediator LPAR1. The discovery of this potent inhibitor opens new avenues for pharmacological applications and therapeutic development targeting the TRPV2 channel. Reference: J Med Chem. 2019 Feb 14;62(3):1373-1384. https://pubmed.ncbi.nlm.nih.gov/30620187/
In vivo activity: To be determined

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 248.29

Preparing Stock Solutions

The following data is based on the product molecular weight 402.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Chai H, Cheng X, Zhou B, Zhao L, Lin X, Huang D, Lu W, Lv H, Tang F, Zhang Q, Huang W, Li Y, Yang H. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62(3):1373-1384. doi: 10.1021/acs.jmedchem.8b01496. Epub 2019 Jan 16. PMID: 30620187.
In vitro protocol: 1. Chai H, Cheng X, Zhou B, Zhao L, Lin X, Huang D, Lu W, Lv H, Tang F, Zhang Q, Huang W, Li Y, Yang H. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62(3):1373-1384. doi: 10.1021/acs.jmedchem.8b01496. Epub 2019 Jan 16. PMID: 30620187.
In vivo protocol: To be determined

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x