1-β-D-Glucosylsphingosine
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MedKoo CAT#: 463157

CAS#: 52050-17-6

Description: 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides. They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells when used at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a concentration-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen and brain, thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingosine (d18:1) isolated from bovine buttermilk.

Chemical Structure

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1-β-D-Glucosylsphingosine
CAS# 52050-17-6
Instruction

Theoretical Analysis

MedKoo Cat#: 463157
Name: 1-β-D-Glucosylsphingosine
CAS#: 52050-17-6
Chemical Formula: C24H47NO7
Exact Mass: 461.34
Molecular Weight: 461.640
Elemental Analysis: C, 62.44; H, 10.26; N, 3.03; O, 24.26

Price and Availability

Size Price Availability Quantity
1mg USD 310 2 Weeks
5mg USD 520 2 Weeks
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Synonym: 1-β-D-Glucosylsphingosine; Glucosyl-C18-sphingosine; Glucosylsphingosine (d18:1); 1-β-D-Glucosylsphingosine (d18:1) (buttermilk);

IUPAC/Chemical Name: (2R,3R,4S,5S,6R)-2-(((2S,3R,E)-2-amino-3-hydroxyoctadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: HHJTWTPUPVQKNA-JIAPQYILSA-N

InChi Code: InChI=1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1

SMILES Code: O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[C@H](N)[C@@H](/C=C/CCCCCCCCCCCCC)O)CO)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 461.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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