ANT2681

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535275

CAS#: N/A

Description: ANT2681 is a novel Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae.

Chemical Structure

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ANT2681
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 535275
Name: ANT2681
CAS#: N/A
Chemical Formula: C12H12F2N8O4S2
Exact Mass: 434.04
Molecular Weight: 434.397
Elemental Analysis: C, 33.18; H, 2.78; F, 8.75; N, 25.80; O, 14.73; S, 14.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ANT2681; ANT-2681; ANT 2681

IUPAC/Chemical Name: 5-((4-(2-Carbamimidoylhydrazine-1-carboxamido)-3,5-difluorophenyl)sulfonamido)thiazole-4-carboxamide

InChi Key: MIBPFKBBDUWQLA-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H12F2N8O4S2/c13-5-1-4(2-6(14)7(5)19-12(24)21-20-11(16)17)28(25,26)22-10-8(9(15)23)18-3-27-10/h1-3,22H,(H2,15,23)(H4,16,17,20)(H2,19,21,24)

SMILES Code: O=C(C1=C(NS(=O)(C2=CC(F)=C(NC(NNC(N)=N)=O)C(F)=C2)=O)SC=N1)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 434.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Das S, Johnson A, McEntee L, Farrington N, Kirby A, Unsworth J, Jimenez- Valverde A, Kolamunnage-Dona R, Bousquet J, Alibaud L, Sable C, Zalacain M, Everett M, Hope W. Pharmacodynamics of the Novel Metallo-ß-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of NDM-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2020 Aug 10:AAC.01076-20. doi: 10.1128/AAC.01076-20. Epub ahead of print. PMID: 32778549.


2: Davies DT, Leiris S, Sprynski N, Castandet J, Lozano C, Bousquet J, Zalacain M, Vasa S, Dasari PK, Pattipati R, Vempala N, Gujjewar S, Godi S, Jallala R, Sathyap RR, Darshanoju NA, Ravu VR, Juventhala RR, Pottabathini N, Sharma S, Pothukanuri S, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Mangani S, Docquier JD, Lemonnier M, Everett M. ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM- Producing Enterobacteriaceae. ACS Infect Dis. 2020 Aug 20. doi: 10.1021/acsinfecdis.0c00207. Epub ahead of print. PMID: 32786279.