Cedirogant | CAS#2055496-11-0 | RORγt Antagonist

Cedirogant
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535186

CAS#: 2055496-11-0

Description: Cedirogant is a retinoid-related orphan receptor-γt (RORγt) antagonist.

Chemical Structure

Cedirogant

CAS# 2055496-11-0

Instruction

Theoretical Analysis

MedKoo Cat#: 535186
Name: Cedirogant
CAS#: 2055496-11-0
Chemical Formula: C24H20Cl3F3N2O3
Exact Mass: 546.05
Molecular Weight: 547.780
Elemental Analysis: C, 52.62; H, 3.68; Cl, 19.41; F, 10.40; N, 5.11; O, 8.76

Price and Availability

Size	Price	Availability
10mg	USD 250	2 Weeks
25mg	USD 450	2 Weeks
50mg	USD 750	2 Weeks
100mg	USD 1250	2 Weeks
200mg	USD 1950	2 Weeks
500mg	USD 3650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Cedirogant; ABBV-157; ABBV 157; ABBV157; WHO 11460; WHO-11460; WHO11460;

IUPAC/Chemical Name: [1-(2,4-dichloro-3-{[7-chloro-5-(trifluoromethyl)-1Hindol-1-yl]methyl}benzoyl)piperidin-4-yl]acetic acid

InChi Key: MNEOHCYSHVKLIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H20Cl3F3N2O3/c25-18-2-1-16(23(35)31-6-3-13(4-7-31)9-20(33)34)21(27)17(18)12-32-8-5-14-10-15(24(28,29)30)11-19(26)22(14)32/h1-2,5,8,10-11,13H,3-4,6-7,9,12H2,(H,33,34)

SMILES Code: O=C(O)CC1CCN(C(C2=CC=C(Cl)C(CN3C=CC4=C3C(Cl)=CC(C(F)(F)F)=C4)=C2Cl)=O)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 547.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Gege C. Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases - where are we presently? Expert Opin Drug Discov. 2021 Dec;16(12):1517-1535. doi: 10.1080/17460441.2021.1948833. Epub 2021 Jul 7. PMID: 34192992.

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