2'-Deoxyguanosine
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MedKoo CAT#: 462448

CAS#: 961-07-9

Description: 2'-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells.

Chemical Structure

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2'-Deoxyguanosine
CAS# 961-07-9
Instruction

Theoretical Analysis

MedKoo Cat#: 462448
Name: 2'-Deoxyguanosine
CAS#: 961-07-9
Chemical Formula: C10H13N5O4
Exact Mass: 267.10
Molecular Weight: 267.245
Elemental Analysis: C, 44.94; H, 4.90; N, 26.21; O, 23.95

Price and Availability

Size Price Availability Quantity
1g USD 215 2 Weeks
5g USD 380 2 Weeks
10g USD 690 2 Weeks
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Synonym: 2'-Deoxyguanosine; Guanine deoxyriboside; NSC 22837; NSC-22837; NSC-22837

IUPAC/Chemical Name: 2-amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one

InChi Key: YKBGVTZYEHREMT-KVQBGUIXSA-N

InChi Code: InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1

SMILES Code: NC1=NC(C(N=CN2[C@]3([H])O[C@H](CO)[C@@H](O)C3)=C2N1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 267.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ross, D.D., Akman, S.A., Schrecker, A.W., et al. Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools. Cancer Res. 41(11 Pt 1), 4493-4498 (1981).

2: Mitchell, B.S., Mejias, E., Daddona, P.E., et al. Purinogenic immunodeficiency diseases: Selective toxicity of deoxyribonucleosides for T cells. Proc. Natl. Acad. Sci. USA 75(10), 5011-5014 (1978).

3: Brulfert, A., Clain, E., and Deysson, G. Deoxyguanosine, a potent cytokinesis inhibitor in plant cells. Experientia 30(9), 1010-1011 (1974).

4: Scholar, E.M. Effect of deoxypurine and deoxypyrimidine compounds on the vascular responsiveness of bovine coronary and lingual arteries. J. Pharm. Pharmacol. 32(10), 726 (1980).