AB-22

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535068

CAS#: 1463913-43-0

Description: AB-22 is a bioactive chemical.

Chemical Structure

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AB-22
CAS# 1463913-43-0
Instruction

Theoretical Analysis

MedKoo Cat#: 535068
Name: AB-22
CAS#: 1463913-43-0
Chemical Formula: C22H30ClN7O3
Exact Mass: 475.21
Molecular Weight: 475.978
Elemental Analysis: C, 55.52; H, 6.35; Cl, 7.45; N, 20.60; O, 10.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AB-22; AB 22; AB22

IUPAC/Chemical Name: Hydrazinecarboxamide, N-(2-chloro-6-propoxy-4-pyridinyl)-2-(1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo(3,4-b)pyridin-6-yl)-2-(2-hydroxyethyl)-

InChi Key: GOQBSVFOBGVWTA-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30ClN7O3/c1-6-9-33-19-11-15(10-17(23)25-19)24-22(32)28-30(7-8-31)18-12-16(13(2)3)20-14(4)27-29(5)21(20)26-18/h10-13,31H,6-9H2,1-5H3,(H2,24,25,28,32)

SMILES Code: OCCN(C1=CC(C(C)C)=C2C(N(C)N=C2C)=N1)NC(NC3=CC(Cl)=NC(OCCC)=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 475.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: MacLaggan TD, Le CP, Iverson KA, Ellis CL, Allard J, Wilcox-Carrier TJ, Smyth DJ. The clinical impact of a urinary tract infection management bundle in a tertiary-care teaching hospital. Infect Control Hosp Epidemiol. 2019 Jan;40(1):72-78. doi: 10.1017/ice.2018.276. Epub 2018 Dec 3. PMID: 30501661.


2: Choi YM, Kim WG, Kim TY, Bae SJ, Kim HK, Jang EK, Jeon MJ, Han JM, Lee SH, Baek JH, Shong YK, Kim WB. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid. 2014 Apr;24(4):655-61. doi: 10.1089/thy.2013.0460. Epub 2014 Jan 30. PMID: 24320141; PMCID: PMC3993051.


3: Pohlen B, Hawlina M, Šober K, Kopač I. Tooth Shade-Matching Ability Between Groups of Students with Different Color Knowledge. Int J Prosthodont. 2016 Sep- Oct;29(5):487-92. doi: 10.11607/ijp.4712. PMID: 27611754.


4: Mandato VD, Torricelli F, Mastrofilippo V, Ciarlini G, Pirillo D, Annunziata G, Casali B, Abrate M, Sala GB, Aguzzoli L. AB0 Blood Group and Ovarian Cancer Survival. J Cancer. 2019 Apr 25;10(9):1949-1957. doi: 10.7150/jca.29272. PMID: 31205554; PMCID: PMC6548162.


5: Skendros P, Boura P, Kamaria F, Raptopoulou-Gigi M. CD80/CD28 co-stimulation in human brucellosis. Clin Exp Immunol. 2006 Dec;146(3):400-8. doi: 10.1111/j.1365-2249.2006.03223.x. Erratum in: Clin Exp Immunol. 2007 Jan;147(1):197. PMID: 17100758; PMCID: PMC1810400.


6: Velasquez-Munoz A, Manriquez D, Paudyal S, Solano G, Han H, Callan R, Velez J, Pinedo P. Effect of a mechanical grooming brush on the behavior and health of recently weaned heifer calves. BMC Vet Res. 2019 Aug 8;15(1):284. doi: 10.1186/s12917-019-2033-3. PMID: 31395062; PMCID: PMC6686348.


7: Strieder TG, Wenzel BE, Prummel MF, Tijssen JG, Wiersinga WM. Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease. Clin Exp Immunol. 2003 May;132(2):278-82. doi: 10.1046/j.1365-2249.2003.02139.x. PMID: 12699417; PMCID: PMC1808711.


8: Maginniss LA, Ekelund SA, Ultsch GR. Blood oxygen transport in common map turtles during simulated hibernation. Physiol Biochem Zool. 2004 Mar- Apr;77(2):232-41. doi: 10.1086/381473. PMID: 15095243.


9: Arck PC, Hertwig K, Hagen E, Hildebrandt M, Klapp BF. Pregnancy as a model of controlled invasion might be attributed to the ratio of CD3/CD8 to CD56. Am J Reprod Immunol. 2000 Jul;44(1):1-8. doi: 10.1111/j.8755-8920.2000.440101.x. PMID: 10976806.


10: Skendros P, Boura P, Chrisagis D, Raptopoulou-Gigi M. Diminished percentage of CD4+ T-lymphocytes expressing interleukine-2 receptor alpha in chronic brucellosis. J Infect. 2007 Feb;54(2):192-7. doi: 10.1016/j.jinf.2006.04.001. Epub 2006 May 23. PMID: 16720045.


11: Baharav E, Gur H, Fishman P, Ziporen L, Blank M, Aelion J, Kotb M, Shoenfeld Y. Superantigens and experimental SLE induced by idiotypic dysregulation. Clin Exp Rheumatol. 1996 Jul-Aug;14(4):359-66. PMID: 8871833.


12: Takeuchi M, Kakiuchi T, Taira S, Nariuchi H. B cells as accessory cells in a Con A response of a T cell clone. Immunobiology. 1987 Dec;176(1-2):1-13. doi: 10.1016/S0171-2985(87)80095-5. PMID: 3129359.


13: Xie J, Joseph KO, Bagby GJ, Giles TD, Greenberg SS. Dissociation of TNF- alpha from endotoxin-induced nitric oxide and acute-phase hypotension. Am J Physiol. 1997 Jul;273(1 Pt 2):H164-74. doi: 10.1152/ajpheart.1997.273.1.H164. PMID: 9249487.


14: Eliasson I. A protein antigen characteristic of Branhamella catarrhalis. Serological identification of the genus. Acta Pathol Microbiol Scand B. 1980 Oct;88(5):281-6. doi: 10.1111/j.1699-0463.1980.tb02642.x. PMID: 6781219.