SGC-AAK1-1
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462340

CAS#: 2247894-32-0

Description: SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor. It also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1.

Chemical Structure

img
SGC-AAK1-1
CAS# 2247894-32-0
Instruction

Theoretical Analysis

MedKoo Cat#: 462340
Name: SGC-AAK1-1
CAS#: 2247894-32-0
Chemical Formula: C21H25N5O3S
Exact Mass: 427.17
Molecular Weight: 427.523
Elemental Analysis: C, 59.00; H, 5.89; N, 16.38; O, 11.23; S, 7.50

Price and Availability

Size Price Availability Quantity
50mg USD 750 2 Weeks
100mg USD 1350 2 Weeks
200mg USD 2150 2 Weeks
500mg USD 3450 2 Weeks
Bulk inquiry

Synonym: SGC-AAK1-1; SGC AAK1-1; SGC-AAK1 1; SGC AAK1 1

IUPAC/Chemical Name: N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide

InChi Key: UCBIQZUJJSVQHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25N5O3S/c1-3-26(4-2)30(28,29)25-17-7-5-6-15(12-17)16-10-11-18-19(13-16)23-24-20(18)22-21(27)14-8-9-14/h5-7,10-14,25H,3-4,8-9H2,1-2H3,(H2,22,23,24,27)

SMILES Code: O=C(C1CC1)NC2=NNC3=C2C=CC(C4=CC=CC(NS(=O)(N(CC)CC)=O)=C4)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 427.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Agajanian MJ, Walker MP, Axtman AD, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26(1):79-93.e8. doi:10.1016/j.celrep.2018.12.023