Chlormerodrin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462110

CAS#: 62-37-3

Description: Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.

Chemical Structure

img
Chlormerodrin
CAS# 62-37-3
Instruction

Theoretical Analysis

MedKoo Cat#: 462110
Name: Chlormerodrin
CAS#: 62-37-3
Chemical Formula: C5H11ClHgN2O2
Exact Mass: 368.02
Molecular Weight: 367.195
Elemental Analysis: C, 16.36; H, 3.02; Cl, 9.65; Hg, 54.63; N, 7.63; O, 8.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Chlormerodrin; Katonil; Clormerodrina; Mercloran; Merculest; Chlormerodrinum; Percapyl; Promeranum; Neohydrin; Merilid

IUPAC/Chemical Name: Mercury, chloro(2-methoxy-3-ureidopropyl)-

InChi Key: BJFGVYCULWBXKF-UHFFFAOYSA-M

InChi Code: InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1

SMILES Code: O=C(N)NCC(OC)C[Hg]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: The Quantitative Measurement of Tubular Chlormerodrin Binding as an Index of Renal Function: A Study of 400 Cases D. L. Tabern, J. Kearney, H. Sohn Can Med Assoc J. 1970 Sep 26; 103(6): 601–607. PMCID: PMC1930528

2: Localization of Erythrocyte Membrane Sulfhydryl Groups Essential for Glucose Transport. J. Vansteveninck, R. I. Weed, A. Rothstein. J Gen Physiol. 1965 Mar 1; 48(4): 617–632. doi: 10.1085/jgp.48.4.617. PMCID: PMC2195434

3: The kidney in hypertension: studies with radioactive chlormerodrin. R. Secker-Walker. Proc R Soc Med. 1967 Jan; 60(1): 41–44.
PMCID: PMC1901408

4: The mechanism of action of mercurial diuretics in rats; the metabolism of 203hg-labelled chlormerodrin. T. W. Clarkson, A. Rothstein, R. Sutherland. Br J Pharmacol Chemother. 1965 Feb; 24(1): 1–13. doi: 10.1111/j.1476-5381.1965.tb02075.x. PMCID: PMC1704042

5: THE DISTRIBUTION OF CHLORMERODRIN (NEOHYDRIN®) IN TISSUES OF THE RAT AND DOG. R. R. M. Borghgraef, R. F. Pitts. J Clin Invest. 1956 Jan; 35(1): 31–37. doi: 10.1172/JCI103249. PMCID: PMC438775

6: Localization of kidney for renal biopsy using chlormerodrin-203Hg. L. Reese, D. Joshi. Can Med Assoc J. 1968 Aug 10; 99(6): 245–247. PMCID: PMC1924393

7: Chlormerodrin: Clinical Effectiveness and Absence of Toxicity in Congestive Heart Failure. William A. Leff, Harvey E. Nussbaum. Br Med J. 1959 Apr 4; 1(5126): 883–889. doi: 10.1136/bmj.1.5126.883. PMCID: PMC1992943

8: PLASMA REGRESSION, DISTRIBUTION AND EXCRETION OF RADIOMERCURY IN RELATION TO DIURESIS FOLLOWING THE INTRAVENOUS ADMINISTRATION OF Hg203 LABELLED CHLORMERODRIN TO THE DOG R. R. M. Borghgraef, R. H. Kessler, R. F. Pitts, M. E. Parks, W. Van Woert, M. B. MacLeod. J Clin Invest. 1956 Sep; 35(9): 1055–1066. doi: 10.1172/JCI103351. PMCID: PMC441680

9: The Role of Radioisotope Renal Scanning in the Assessment of Renal Disease. Leonard Rosenthall. Can Med Assoc J. 1964 Apr 25; 90(17): 999–1004. PMCID: PMC1922682

10: Mercury 197 chlormerodrin in the diagnosis of intraocular tumours. J M Cappin, D P Greaves. Br J Ophthalmol. 1972 Nov; 56(11): 805–811. doi: 10.1136/bjo.56.11.805. PMCID: PMC1214748