Royleanone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585019

CAS#: 6812-87-9

Description: Royleanone is a diterpenoid that exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway.

Chemical Structure

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Royleanone
CAS# 6812-87-9
Instruction

Theoretical Analysis

MedKoo Cat#: 585019
Name: Royleanone
CAS#: 6812-87-9
Chemical Formula: C20H28O3
Exact Mass: 316.20
Molecular Weight: 316.441
Elemental Analysis: C, 75.91; H, 8.92; O, 15.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Royleanone

IUPAC/Chemical Name: 1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bs-trans)-

InChi Key: KZAPVZIQILABNM-RBZFPXEDSA-N

InChi Code: InChI=1S/C20H28O3/c1-11(2)14-16(21)12-7-8-13-19(3,4)9-6-10-20(13,5)15(12)18(23)17(14)22/h11,13,22H,6-10H2,1-5H3/t13-,20-/m0/s1

SMILES Code: O=C1C(C(C)C)=C(O)C(C2=C1CC[C@@]3([H])C(C)(C)CCC[C@]23C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 316.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li CJ, Xia F, Wu R, Tan HS, Xu HX, Xu G, Qin HB. Synthesis and Cytotoxicities of Royleanone Derivatives. Nat Prod Bioprospect. 2018 Dec;8(6):453-456. doi: 10.1007/s13659-018-0173-y. Epub 2018 Jun 16. PubMed PMID: 29909523; PubMed Central PMCID: PMC6224808.

2: Wu X, He Y, Zhang G, Wu J, Hou Y, Gu Y, Chen H. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. PubMed PMID: 30358211.

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5: Xu S, Ma X, Ke R, Deng S, Yang X, Song P. Crystal structure of 7β-hy-droxy-royleanone isolated from Taxodium ascendens (B.). Acta Crystallogr E Crystallogr Commun. 2017 Sep 5;73(Pt 10):1414-1416. doi: 10.1107/S2056989017011987. eCollection 2017 Oct 1. PubMed PMID: 29250348; PubMed Central PMCID: PMC5730285.

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7: Rijo P, Simões MF, Francisco AP, Rojas R, Gilman RH, Vaisberg AJ, Rodríguez B, Moiteiro C. Antimycobacterial metabolites from Plectranthus: royleanone derivatives against Mycobacterium tuberculosis strains. Chem Biodivers. 2010 Apr;7(4):922-32. doi: 10.1002/cbdv.200900099. PubMed PMID: 20397225.

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13: Alegre-Gómez S, Sainz P, Simões MF, Rijo P, Moiteiro C, González-Coloma A, Martínez-Díaz RA. Antiparasitic Activity of Diterpenoids Against Trypanosoma cruzi. Planta Med. 2017 Feb;83(3-04):306-311. doi: 10.1055/s-0042-115646. Epub 2016 Sep 6. PubMed PMID: 27599261.

14: Fronza M, Lamy E, Günther S, Heinzmann B, Laufer S, Merfort I. Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action. Phytochemistry. 2012 Jun;78:107-19. doi: 10.1016/j.phytochem.2012.02.015. Epub 2012 Mar 19. PubMed PMID: 22436445.

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16: Cerqueira F, Cordeiro-Da-Silva A, Gaspar-Marques C, Simões F, Pinto MM, Nascimento MS. Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation. Bioorg Med Chem. 2004 Jan 2;12(1):217-23. PubMed PMID: 14697786.

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