Lycopsamine `1-acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530275

CAS#: 73544-48-6

Description: Lycopsamine `1-acetate is a bioactive chemical.

Chemical Structure

img
Lycopsamine `1-acetate
CAS# 73544-48-6
Instruction

Theoretical Analysis

MedKoo Cat#: 530275
Name: Lycopsamine `1-acetate
CAS#: 73544-48-6
Chemical Formula: C17H27NO6
Exact Mass: 341.18
Molecular Weight: 341.404
Elemental Analysis: C, 59.81; H, 7.97; N, 4.10; O, 28.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lycopsamine `1-acetate

IUPAC/Chemical Name: Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, ((1R,7aR)-1-(acetyloxy)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)methyl ester, (2S,3S)-

InChi Key: RKDOFSJTBIDAHX-OFSOMGBPSA-N

InChi Code: InChI=1S/C17H27NO6/c1-10(2)17(22,11(3)19)16(21)23-9-13-5-7-18-8-6-14(15(13)18)24-12(4)20/h5,10-11,14-15,19,22H,6-9H2,1-4H3/t11-,14+,15+,17-/m0/s1

SMILES Code: C[C@H](O)[C@](C(C)C)(O)C(OCC1=CCN2[C@@]1([H])[C@H](OC(C)=O)CC2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 341.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Xia X, Yao Y, Li C, Zhang F, Qu K, Chen H, Huang B, Lei C. Genetic diversity of Chinese cattle revealed by Y-SNP and Y-STR markers. Anim Genet. 2018 Nov 13. doi: 10.1111/age.12742. [Epub ahead of print] PubMed PMID: 30421442.

2: Hanif Q, Farooq M, Amin I, Mansoor S, Zhang Y, Khan QM. In silico identification of conserved miRNAs and their selective target gene prediction in indicine (Bos indicus) cattle. PLoS One. 2018 Oct 26;13(10):e0206154. doi: 10.1371/journal.pone.0206154. eCollection 2018. PubMed PMID: 30365525; PubMed Central PMCID: PMC6203363.

3: Rückert C, Emmerich I, Hertzsch R, Vervuert I. Pyrrolizidine alkaloids in commercial feedstuffs for horses. Equine Vet J. 2018 Oct 24. doi: 10.1111/evj.13033. [Epub ahead of print] PubMed PMID: 30353948.

4: Jin J, Li H, Zhao G, Jiang S. Lycopsamine Exerts Protective Effects and Improves Functional Outcome After Spinal Cord Injury in Rats by Suppressing Cell Death. Med Sci Monit. 2018 Oct 18;24:7444-7450. doi: 10.12659/MSM.912978. PubMed PMID: 30335732; PubMed Central PMCID: PMC6202880.

5: Fonseca PAS, Dos Santos FC, Lam S, Suárez-Vega A, Miglior F, Schenkel FS, Diniz LAF, Id-Lahoucine S, Carvalho MRS, Cánovas A. Genetic mechanisms underlying spermatic and testicular traits within and among cattle breeds: systematic review and prioritization of GWAS results. J Anim Sci. 2018 Dec 3;96(12):4978-4999. doi: 10.1093/jas/sky382. PubMed PMID: 30304443; PubMed Central PMCID: PMC6276581.

6: Peripolli E, Metzger J, de Lemos MVA, Stafuzza NB, Kluska S, Olivieri BF, Feitosa FLB, Berton MP, Lopes FB, Munari DP, Lôbo RB, Magnabosco CU, Di Croce F, Osterstock J, Denise S, Pereira ASC, Baldi F. Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits. BMC Genomics. 2018 Sep 17;19(1):680. doi: 10.1186/s12864-018-5060-8. PubMed PMID: 30223795; PubMed Central PMCID: PMC6142381.

7: Dobler S, Zintgraf V, Haberer W, Paul A. Ontogeny of Defensive Chemistry in Longitarsus Flea Beetles (Coleoptera, Chrysomelidae): More Protection for the Vulnerable Stages? J Chem Ecol. 2018 Aug 31. doi: 10.1007/s10886-018-1010-9. [Epub ahead of print] PubMed PMID: 30167919.

8: Stafuzza NB, Silva RMO, Peripolli E, Bezerra LAF, Lôbo RB, Magnabosco CU, Di Croce FA, Osterstock JB, Munari DP, Lourenco DAL, Baldi F. Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle. PLoS One. 2018 Aug 30;13(8):e0202978. doi: 10.1371/journal.pone.0202978. eCollection 2018. PubMed PMID: 30161212; PubMed Central PMCID: PMC6116989.

9: Zeng L, Chen N, Ning Q, Yao Y, Chen H, Dang R, Zhang H, Lei C. PRLH and SOD1 gene variations associated with heat tolerance in Chinese cattle. Anim Genet. 2018 Oct;49(5):447-451. doi: 10.1111/age.12702. Epub 2018 Aug 5. PubMed PMID: 30079537.

10: Mukherjee A, Mukherjee S, Dhakal R, Mech M, Longkumer I, Haque N, Vupru K, Khate K, Jamir IY, Pongen P, Rajkhowa C, Mitra A, Guldbrandtsen B, Sahana G. High-density Genotyping reveals Genomic Characterization, Population Structure and Genetic Diversity of Indian Mithun (Bos frontalis). Sci Rep. 2018 Jul 9;8(1):10316. doi: 10.1038/s41598-018-28718-x. PubMed PMID: 29985484; PubMed Central PMCID: PMC6037757.

11: Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018 Nov;29(6):613-626. doi: 10.1002/pca.2775. Epub 2018 Jul 2. PubMed PMID: 29968391.

12: Chen N, Cai Y, Chen Q, Li R, Wang K, Huang Y, Hu S, Huang S, Zhang H, Zheng Z, Song W, Ma Z, Ma Y, Dang R, Zhang Z, Xu L, Jia Y, Liu S, Yue X, Deng W, Zhang X, Sun Z, Lan X, Han J, Chen H, Bradley DG, Jiang Y, Lei C. Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia. Nat Commun. 2018 Jun 14;9(1):2337. doi: 10.1038/s41467-018-04737-0. PubMed PMID: 29904051; PubMed Central PMCID: PMC6002414.

13: Leal WS, MacNeil MD, Carvalho HG, Vaz RZ, Cardoso FF. Direct and maternal breed additive and heterosis effects on growth traits of beef cattle raised in southern Brazil. J Anim Sci. 2018 Jun 29;96(7):2536-2544. doi: 10.1093/jas/sky160. PubMed PMID: 29741708; PubMed Central PMCID: PMC6095372.

14: Honda K, Matsumoto J, Sasaki K, Tsuruta Y, Honda Y. Uptake of plant-derived specific alkaloids allows males of a butterfly to copulate. Sci Rep. 2018 Apr 3;8(1):5516. doi: 10.1038/s41598-018-23917-y. PubMed PMID: 29615771; PubMed Central PMCID: PMC5882650.

15: DeAtley KL, Colgrave ML, Cánovas A, Wijffels G, Ashley RL, Silver GA, Rincon G, Medrano JF, Islas-Trejo A, Fortes MRS, Reverter A, Porto-Neto L, Lehnert SA, Thomas MG. Neuropeptidome of the Hypothalamus and Pituitary Gland of Indicine × Taurine Heifers: Evidence of Differential Neuropeptide Processing in the Pituitary Gland before and after Puberty. J Proteome Res. 2018 May 4;17(5):1852-1865. doi: 10.1021/acs.jproteome.7b00875. Epub 2018 Apr 6. PubMed PMID: 29510626.

16: Bahbahani H, Salim B, Almathen F, Al Enezi F, Mwacharo JM, Hanotte O. Signatures of positive selection in African Butana and Kenana dairy zebu cattle. PLoS One. 2018 Jan 4;13(1):e0190446. doi: 10.1371/journal.pone.0190446. eCollection 2018. PubMed PMID: 29300786; PubMed Central PMCID: PMC5754058.

17: Mei C, Wang H, Liao Q, Wang L, Cheng G, Wang H, Zhao C, Zhao S, Song J, Guang X, Liu GE, Li A, Wu X, Wang C, Fang X, Zhao X, Smith SB, Yang W, Tian W, Gui L, Zhang Y, Hill RA, Jiang Z, Xin Y, Jia C, Sun X, Wang S, Yang H, Wang J, Zhu W, Zan L. Genetic architecture and selection of Chinese cattle revealed by whole genome resequencing. Mol Biol Evol. 2017 Dec 19. doi: 10.1093/molbev/msx322. [Epub ahead of print] PubMed PMID: 29294071.

18: Gao Y, Gautier M, Ding X, Zhang H, Wang Y, Wang X, Faruque MO, Li J, Ye S, Gou X, Han J, Lenstra JA, Zhang Y. Species composition and environmental adaptation of indigenous Chinese cattle. Sci Rep. 2017 Nov 23;7(1):16196. doi: 10.1038/s41598-017-16438-7. PubMed PMID: 29170422; PubMed Central PMCID: PMC5700937.

19: Manirakiza J, Hatungumukama G, Thévenon S, Gautier M, Besbes B, Flori L, Detilleux J. Effect of genetic European taurine ancestry on milk yield of Ankole-Holstein crossbred dairy cattle in mixed smallholders system of Burundi highlands. Anim Genet. 2017 Oct;48(5):544-550. doi: 10.1111/age.12578. Epub 2017 Aug 21. PubMed PMID: 28833335.

20: Ahmad L, He Y, Hao JC, Semotiuk A, Liu QR, Mazari P. Toxic pyrrolizidine alkaloids provide a warning sign to overuse of the ethnomedicine Arnebia benthamii. J Ethnopharmacol. 2018 Jan 10;210:88-94. doi: 10.1016/j.jep.2017.08.009. Epub 2017 Aug 12. PubMed PMID: 28807851.