LY-368975 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529189

CAS#: 222961-65-1

Description: LY-368975 hydrochloride is a bioactive chemical.

Chemical Structure

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LY-368975 hydrochloride
CAS# 222961-65-1
Instruction

Theoretical Analysis

MedKoo Cat#: 529189
Name: LY-368975 hydrochloride
CAS#: 222961-65-1
Chemical Formula: C17H22ClNOS
Exact Mass: 323.11
Molecular Weight: 323.879
Elemental Analysis: C, 63.04; H, 6.85; Cl, 10.95; N, 4.32; O, 4.94; S, 9.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LY-368975 hydrochloride

IUPAC/Chemical Name: (R)-N-Methyl-3-(2-(methylthio)phenoxy)-3-phenylpropanamine hydrochloride

InChi Key: HFMCAKLVRSTANX-XFULWGLBSA-N

InChi Code: InChI=1S/C17H21NOS.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)19-16-10-6-7-11-17(16)20-2;/h3-11,15,18H,12-13H2,1-2H3;1H/t15-;/m1./s1

SMILES Code: CSC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 323.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jones CK, Eastwood BJ, Need AB, Shannon HE. Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology. 2006 Dec;51(7-8):1172-80. Epub 2006 Oct 11. PubMed PMID: 17045620.

2: Iyengar S, Webster AA, Hemrick-Luecke SK, Xu JY, Simmons RM. Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. J Pharmacol Exp Ther. 2004 Nov;311(2):576-84. Epub 2004 Jul 13. PubMed PMID: 15254142.

3: Katofiasc MA, Nissen J, Audia JE, Thor KB. Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats. Life Sci. 2002 Aug 2;71(11):1227-36. PubMed PMID: 12106588.

4: Gehlert DR, Dreshfield L, Tinsley F, Benvenga MJ, Gleason S, Fuller RW, Wong DT, Hemrick-Luecke SK. The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding. J Pharmacol Exp Ther. 1998 Oct;287(1):122-7. PubMed PMID: 9765330.