Ciclonicate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461400

CAS#: 53449-58-4

Description: Ciclonicate is a vasodilator.

Chemical Structure

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Ciclonicate
CAS# 53449-58-4
Instruction

Theoretical Analysis

MedKoo Cat#: 461400
Name: Ciclonicate
CAS#: 53449-58-4
Chemical Formula: C15H21NO2
Exact Mass: 247.16
Molecular Weight: 247.330
Elemental Analysis: C, 72.84; H, 8.56; N, 5.66; O, 12.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ciclonicate; Cortofludan; Elastan; Rolil; Vasargil; P-350; P 350; P350;

IUPAC/Chemical Name: (1R,5S)-3,3,5-trimethylcyclohexyl nicotinate

InChi Key: GQSGZTBDVNUIQS-DGCLKSJQSA-N

InChi Code: InChI=1S/C15H21NO2/c1-11-7-13(9-15(2,3)8-11)18-14(17)12-5-4-6-16-10-12/h4-6,10-11,13H,7-9H2,1-3H3/t11-,13-/m1/s1

SMILES Code: O=C(C1=CC=CN=C1)O[C@H]2CC(C)(C)C[C@H](C)C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 247.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Licata G, Pinto A, Parrinello G, Salli L, Indovina I. [Use of ciclonicate in the treatment of obliterative arteriopathies of the lower limbs]. Clin Ter. 1985 Mar 31;112(6):503-13. Italian. PubMed PMID: 4017475.

2: Gregoratti L, Crespi B, Groothold G, Fuligni E, Ghiringhelli L. [Treatment of arteriosclerotic peripheral vascular diseases with ciclonicate]. Minerva Cardioangiol. 1982 Nov;30(11):659-68. Italian. PubMed PMID: 7155375.

3: Feliciotti F, De Carolis G, Mariotti C, Mingolla F. [Clinico-instrumental evaluation of ciclonicate in the therapy of obliterating arteriopathies of the lower extremities in Fontaine's stage II]. Ann Ital Chir. 1983;55(5):493-7. Italian. PubMed PMID: 6673630.

4: Faini D, Pagella PG, Bellavite O, Turba C. Long-lasting antilipolytic action of cyclonicate in rats. Farmaco Prat. 1981 Oct;36(10):478-85. PubMed PMID: 7308421.

5: Alvisi V, Strozzi C. [Clinical evaluation of cyclonicate in atherosclerotic coronary arteriopathy]. Minerva Cardioangiol. 1982 Apr;30(4):209-11. Italian. PubMed PMID: 7088305.

6: Tessari F, Caparrotta L, Gaion RM, Fassina G. Effect of cyclonicate, a new hypolipemic drug, on lipolysis in vitro. Farmaco Sci. 1981 Dec;36(12):1029-36. PubMed PMID: 6274681.