Chlornaphazine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461046

CAS#: 494-03-1

Description: Chlornaphazine is a antineoplastic agent and has been identified as a human carcinogen.

Chemical Structure

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Chlornaphazine
CAS# 494-03-1
Instruction

Theoretical Analysis

MedKoo Cat#: 461046
Name: Chlornaphazine
CAS#: 494-03-1
Chemical Formula: C14H15Cl2N
Exact Mass: 267.06
Molecular Weight: 268.180
Elemental Analysis: C, 62.70; H, 5.64; Cl, 26.44; N, 5.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Chlornaphazine; CB 1048; CB-1048; CB1048; Erysan; R 48; R-48; R48; SK 2406; SK-2406; SK2406;

IUPAC/Chemical Name: N,N-bis(2-chloroethyl)naphthalen-2-amine

InChi Key: XCDXSSFOJZZGQC-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H15Cl2N/c15-7-9-17(10-8-16)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11H,7-10H2

SMILES Code: ClCCN(C1=CC=C2C=CC=CC2=C1)CCCl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 268.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Barnett LB, Lewis SE. Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice. Mutat Res. 2003 Mar;543(2):145-54. PubMed PMID: 12644184.

2: Laursen B. Cancer of the bladder in patients treated with chlornaphazine. Br Med J. 1970 Sep 19;3(5724):684-5. PubMed PMID: 5470116; PubMed Central PMCID: PMC1701774.

3: THIEDE T, CHIEVITZ E, CHRISTENSEN BC. CHLORNAPHAZINE AS A BLADDER CARCINOGEN. Acta Med Scand. 1964 Jun;175:721-5. PubMed PMID: 14171978.

4: Ashby J, Loquet C, Ishidate M Jr, Callander RD, Albanese R. Mutagenicity to bacteria, cultured cells, and rodents of the human carcinogen chlornaphazine. Environ Mol Mutagen. 1988;12(4):365-74. PubMed PMID: 3056719.

5: Thiede T, Christensen BC. [Bladder tumors induced by chlornaphazine treatment]. Ugeskr Laeger. 1975 Mar 17;137(12):661-6. Danish. PubMed PMID: 1145787.

6: Clemmesen J, Hjalgrim-Jensen S. Epidemiological studies of medically used drugs. Arch Toxicol Suppl. 1980;3:19-25. PubMed PMID: 6930943.

7: Thiede T, Christensen BC. Bladder tumours induced by chlornaphazine. A five-year follow-up study of chlornaphazine-treated patients with polycythaemia. Acta Med Scand. 1969 Jan-Feb;185(1-2):133-7. PubMed PMID: 5257690.

8: Schmähl D. Iatrogenic carcinogenesis. J Cancer Res Clin Oncol. 1981;99(1-2):71-5. PubMed PMID: 7251640.

9: Vineis P, Pirastu R. Aromatic amines and cancer. Cancer Causes Control. 1997 May;8(3):346-55. Review. PubMed PMID: 9498898.

10: Murta-Nascimento C, Schmitz-Dräger BJ, Zeegers MP, Steineck G, Kogevinas M, Real FX, Malats N. Epidemiology of urinary bladder cancer: from tumor development to patient's death. World J Urol. 2007 Jun;25(3):285-95. Review. PubMed PMID: 17530260.

11: Vesely DL, Levey GS. Inhibition of nitroso chemical carcinogen activation of rat hepatic guanylate cyclase by anticancer agents. Oncology. 1979;36(3):122-6. PubMed PMID: 38420.