Oxprenolol hydrochloride
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MedKoo CAT#: 584123

CAS#: 6452-73-9

Description: Oxprenolol hydrochloride is a non-selective beta-adrenergic blocking agent that also possesses intrinsic sympathomimetic activity (ISA) and membrane stabilizing effects. Oxprenolol hydrochloride undergoes first pass metabolism with only 30% of an oral dose reaching the systemic circulation. The drug is approximately 80% protein bound and is eliminated primarily by glucuronidation in the liver. Less than 4% of oxprenolol hydrochloride is excreted unchanged in the urine. Oxprenolol hydrochloride may reduce the heart rate and prolong the effective and functional atrioventricular nodal refractory period. It appears to be comparable to other beta blockers in the treatment of hypertension and angina pectoris with no additional adverse reactions.


Chemical Structure

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Oxprenolol hydrochloride
CAS# 6452-73-9

Theoretical Analysis

MedKoo Cat#: 584123
Name: Oxprenolol hydrochloride
CAS#: 6452-73-9
Chemical Formula: C15H24ClNO3
Exact Mass: 0.00
Molecular Weight: 301.811
Elemental Analysis: C, 59.69; H, 8.02; Cl, 11.75; N, 4.64; O, 15.90

Price and Availability

Size Price Availability Quantity
100mg USD 180
1g USD 460
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Synonym: Oxprenolol hydrochloride; Coretal; Dialicor; Rixiprol; Trasicor; Evinrozit; Ranidrox; Oxprenolol HCl; Trepress; Vrachor; Ba 39089; Ba-39089; Ba39089

IUPAC/Chemical Name: 2-Propanol, 1-(o-allyloxyphenoxy)-3-isopropylamino-, hydrochloride

InChi Key: COAJXCLTPGGDAJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H23NO3.ClH/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3;/h4-8,12-13,16-17H,1,9-11H2,2-3H3;1H

SMILES Code: OC(CNC(C)C)COC1=CC=CC=C1OCC=C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Safety Data Sheet (SDS):
Biological target: Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 33.0 109.34
DMSO 137.5 455.58
Ethanol 33.0 109.34
PBS (pH 7.2) 10.0 33.13
Water 100.0 331.33

Preparing Stock Solutions

The following data is based on the product molecular weight 301.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Devi KP, Rao KV, Baveja S, Fathi M, Roth M. Zero-order release formulation of oxprenolol hydrochloride with swelling and erosion control. Pharm Res. 1989 Apr;6(4):313-7. PubMed PMID: 2748519.

2: Russo ME, Covinsky JO. Oxprenolol hydrochloride: pharmacology, pharmacokinetics, adverse effects and clinical efficacy. Pharmacotherapy. 1983 Mar-Apr;3(2 Pt 1):68-81. Review. PubMed PMID: 6344036.

3: Tarpley EL. Oxprenolol hydrochloride: a long-term study of efficacy, safety, and tolerability. Pharmacotherapy. 1982 Sep-Oct;2(5):281-4. PubMed PMID: 6820501.