MDK-4624

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530991

CAS#: 1243184-62-4

Description: MDK-4624, also known as AMPKα1 activator C13, is a AMPKα1 activator. MDK-4624 has CAS#1243184-62-4. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 potently inhibits melanoma cell proliferation.

Chemical Structure

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MDK-4624
CAS# 1243184-62-4
Instruction

Theoretical Analysis

MedKoo Cat#: 530991
Name: MDK-4624
CAS#: 1243184-62-4
Chemical Formula: C17H22NO10P
Exact Mass: 431.10
Molecular Weight: 431.334
Elemental Analysis: C, 47.34; H, 5.14; N, 3.25; O, 37.09; P, 7.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MDK-4624; MDK4624; MDK 4624; AMPKα1 activator C13; C13, Compound 13.

IUPAC/Chemical Name: (((5-(5-oxo-4,5-dihydroisoxazol-3-yl)furan-2-yl)phosphoryl)bis(oxy))bis(methylene) bis(2-methylpropanoate)

InChi Key: NNMZZIPZHAKTQH-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H22NO10P/c1-10(2)16(20)23-8-25-29(22,26-9-24-17(21)11(3)4)15-6-5-13(27-15)12-7-14(19)28-18-12/h5-6,10-11H,7-9H2,1-4H3

SMILES Code: CC(C)C(OCOP(C1=CC=C(C(C2)=NOC2=O)O1)(OCOC(C(C)C)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 431.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhou C, Gu J, Zhang G, Dong D, Yang Q, Chen MB, Xu D. AMPK-autophagy
inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity.
Oncotarget. 2017 Feb 28;8(9):14736-14747. doi: 10.18632/oncotarget.14718. PubMed
PMID: 28103582; PubMed Central PMCID: PMC5362439.


2: Guo S, Mao L, Ji F, Wang S, Xie Y, Fei H, Wang XD. Activating AMP-activated
protein kinase by an α1 selective activator compound 13 attenuates
dexamethasone-induced osteoblast cell death. Biochem Biophys Res Commun. 2016 Mar
18;471(4):545-52. doi: 10.1016/j.bbrc.2016.02.036. Epub 2016 Feb 15. PubMed PMID:
26891866.


3: Hu X, Jiang F, Bao Q, Qian H, Fang Q, Shao Z. Compound 13, an α1-selective
small molecule activator of AMPK, potently inhibits melanoma cell proliferation.
Tumour Biol. 2016 Jan;37(1):1071-8. doi: 10.1007/s13277-015-3854-8. Epub 2015 Aug
14. PubMed PMID: 26271666.


4: Zhao H, Zhu H, Lin Z, Lin G, Lv G. Compound 13, an α1-selective small molecule
activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and
gastric epithelial cell apoptosis. Biochem Biophys Res Commun. 2015 Aug
7;463(4):510-7. doi: 10.1016/j.bbrc.2015.05.059. Epub 2015 May 27. PubMed PMID:
26022128.