AG-494
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407853

CAS#: 133550-35-3

Description: AG-494, also known as Tyrphostin AG-494, is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 µM in HT-22 cells


Price and Availability

Size
Price

10mg
USD 185
Size
Price

25mg
USD 350
Size
Price

50mg
USD 550

AG-494, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407853
Name: AG-494
CAS#: 133550-35-3
Chemical Formula: C16H12N2O3
Exact Mass: 280.0848
Molecular Weight: 280.283
Elemental Analysis: C, 68.56; H, 4.32; N, 9.99; O, 17.12


Synonym: AG-494; AG 494; AG494; Tyrphostin AG-494.

IUPAC/Chemical Name: 2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide

InChi Key: HKHOVJYOELRGMV-XYOKQWHBSA-N

InChi Code: InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+

SMILES Code: O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bojko A, Cierniak A, Adamczyk A, Ligeza J. Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells. Nutr Cancer. 2015;67(7):1170-82. doi: 10.1080/01635581.2015.1073764. Epub 2015 Sep 12. PubMed PMID: 26364505.

2: Liu X, Qin J, Luo Q, Bi Y, Zhu G, Jiang W, Kim SH, Li M, Su Y, Nan G, Cui J, Zhang W, Li R, Chen X, Kong Y, Zhang J, Wang J, Rogers MR, Zhang H, Shui W, Zhao C, Wang N, Liang X, Wu N, He Y, Luu HH, Haydon RC, Shi LL, Li T, He TC, Li M. Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. J Cell Mol Med. 2013 Sep;17(9):1160-72. doi: 10.1111/jcmm.12097. Epub 2013 Jul 11. PubMed PMID: 23844832; PubMed Central PMCID: PMC4118175.

3: Bojko A, Reichert K, Adamczyk A, Ligęza J, Ligęza J, Klein A. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95. PubMed PMID: 22763976.

4: Kasai S, Kikuchi H. The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. Biosci Biotechnol Biochem. 2010;74(1):36-43. Epub 2010 Jan 7. PubMed PMID: 20057149.

5: Kang JL, Lee K, Castranova V. Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants. Mol Cell Biochem. 2000 Dec;215(1-2):1-9. PubMed PMID: 11204443.

6: Kang JL, Go YH, Hur KC, Castranova V. Silica-induced nuclear factor-kappaB activation: involvement of reactive oxygen species and protein tyrosine kinase activation. J Toxicol Environ Health A. 2000 May 12;60(1):27-46. PubMed PMID: 10832616.

7: Becker BN, Kondo S, Chen JK, Harris RC. Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. J Recept Signal Transduct Res. 1999 Nov;19(6):975-93. PubMed PMID: 10533984.

8: Kleinberger-Doron N, Shelah N, Capone R, Gazit A, Levitzki A. Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. Exp Cell Res. 1998 Jun 15;241(2):340-51. PubMed PMID: 9637776.

9: Osherov N, Levitzki A. Tyrphostin AG 494 blocks Cdk2 activation. FEBS Lett. 1997 Jun 30;410(2-3):187-90. PubMed PMID: 9237626.