SC75741
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530988

CAS#: 913822-46-5

Description: SC75741 is a NF-kappaB inhibitor. SC75741 protects mice against highly pathogenic avian influenza A virus. SC75741 significantly protects mice against infection with highly pathogenic avian influenza A viruses of the H5N1 and H7N7 subtypes. SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance.


Price and Availability

Size
Price

500mg
USD 3150
Size
Price

1g
USD 4250
Size
Price

2g
USD 5650

SC-75741, purity > 98%, is in stock. Current shipping out time is about 3-4 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530988
Name: SC75741
CAS#: 913822-46-5
Chemical Formula: C29H23N7O2S2
Exact Mass: 565.1355
Molecular Weight: 565.67
Elemental Analysis: C, 61.58; H, 4.10; N, 17.33; O, 5.66; S, 11.34


Synonym: SC75741; SC-75741; SC 75741.

IUPAC/Chemical Name: N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide

InChi Key: QNZVBFMXWNWVKG-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H23N7O2S2/c37-24(17-4-2-1-3-5-17)19-6-7-20-22(14-19)34-29(33-20)35-27(38)23-15-40-28(32-23)18-8-11-36(12-9-18)26-25-21(10-13-39-25)30-16-31-26/h1-7,10,13-16,18H,8-9,11-12H2,(H2,33,34,35,38)

SMILES Code: O=C(C1=CSC(C2CCN(C3=C4C(C=CS4)=NC=N3)CC2)=N1)NC5=NC6=CC=C(C(C7=CC=CC=C7)=O)C=C6N5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lai Y, Fan L, Zhao Y, Ge H, Feng X, Wang Q, Zhang X, Peng Y, Wang X, Tao L.
Cx32 suppresses extrinsic apoptosis in human cervical cancer cells via the NF‑κB
signalling pathway. Int J Oncol. 2017 Oct;51(4):1159-1168. doi:
10.3892/ijo.2017.4106. Epub 2017 Aug 29. PubMed PMID: 28902345.

2: Haasbach E, Reiling SJ, Ehrhardt C, Droebner K, Rückle A, Hrincius ER, Leban
J, Strobl S, Vitt D, Ludwig S, Planz O. The NF-kappaB inhibitor SC75741 protects
mice against highly pathogenic avian influenza A virus. Antiviral Res. 2013
Sep;99(3):336-44. doi: 10.1016/j.antiviral.2013.06.008. Epub 2013 Jun 28. PubMed
PMID: 23811282.

3: Ehrhardt C, Rückle A, Hrincius ER, Haasbach E, Anhlan D, Ahmann K, Banning C,
Reiling SJ, Kühn J, Strobl S, Vitt D, Leban J, Planz O, Ludwig S. The NF-κB
inhibitor SC75741 efficiently blocks influenza virus propagation and confers a
high barrier for development of viral resistance. Cell Microbiol. 2013
Jul;15(7):1198-211. doi: 10.1111/cmi.12108. Epub 2013 Feb 5. PubMed PMID:
23320394.