Inarigivir

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MedKoo CAT#: 329882

CAS#: 475650-36-3 (free)

Description: Inarigivir, also known as ORI-9020 and SB-9000, is a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA (P

Chemical Structure

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Inarigivir
CAS# 475650-36-3 (free)
Instruction

Theoretical Analysis

MedKoo Cat#: 329882
Name: Inarigivir
CAS#: 475650-36-3 (free)
Chemical Formula: C20H26N7O10PS
Exact Mass: 587.12
Molecular Weight: 587.501
Elemental Analysis: C, 40.89; H, 4.46; N, 16.69; O, 27.23; P, 5.27; S, 5.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 942123-43-5 (soproxil)   475650-36-3 (free)   2172788-92-8 (ammonium)    

Synonym: Inarigivir; ORI-9020; ORI 9020; ORI9020; SB-40; SB-9000; SB9000, SB-9000.

IUPAC/Chemical Name: O-(((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) O-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) S-hydrogen phosphorothioate

InChi Key: LYMICVBGNUEHGE-FUQPUAIBSA-N

InChi Code: InChI=1S/C20H26N7O10PS/c1-33-16-15(10(5-28)36-19(16)26-3-2-12(30)25-20(26)31)37-38(32,39)34-6-11-9(29)4-13(35-11)27-8-24-14-17(21)22-7-23-18(14)27/h2-3,7-11,13,15-16,19,28-29H,4-6H2,1H3,(H,32,39)(H2,21,22,23)(H,25,30,31)/t9-,10+,11+,13+,15+,16+,19+,38?/m0/s1

SMILES Code: O=P(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)C[C@@H]1O)(S)O[C@@H]4[C@@H](CO)O[C@@H](N(C(N5)=O)C=CC5=O)[C@@H]4OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 587.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Iyer RP, Roland A, Jin Y, Mounir S, Korba B, Julander JG, Morrey JD.
Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate
dinucleotide, in a transgenic mouse model. Antimicrob Agents Chemother. 2004
Jun;48(6):2318-20. PubMed PMID: 15155244; PubMed Central PMCID: PMC415565.


2: Iyer RP, Jin Y, Roland A, Morrey JD, Mounir S, Korba B. Phosphorothioate di-
and trinucleotides as a novel class of anti-hepatitis B virus agents. Antimicrob
Agents Chemother. 2004 Jun;48(6):2199-205. PubMed PMID: 15155222; PubMed Central
PMCID: PMC415564.