BC-23

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561559

CAS#: 6298-15-3

Description: BC-23 is an inhibitor of the ß-catenin/Tcf4 interaction. It acts as a potent cell death enhancer when used in combination with radiation.


Price and Availability

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BC-23 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561559
Name: BC-23
CAS#: 6298-15-3
Chemical Formula: C21H14ClN3O4S
Exact Mass: 439.0394
Molecular Weight: 439.87
Elemental Analysis: C, 57.34; H, 3.21; Cl, 8.06; N, 9.55; O, 14.55; S, 7.29


Synonym: BC-23; BC 23; BC23; NSC-45382; NSC 45382; NSC45382;

IUPAC/Chemical Name: 4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]-N-pyridin-2-ylbenzenesulfonamide

InChi Key: QRPKNPKHGNUFGK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H14ClN3O4S/c22-18-19(21(27)16-6-2-1-5-15(16)20(18)26)24-13-8-10-14(11-9-13)30(28,29)25-17-7-3-4-12-23-17/h1-12,24H,(H,23,25)

SMILES Code: O=S(C1=CC=C(NC(C2=O)=C(Cl)C(C3=C2C=CC=C3)=O)C=C1)(NC4=NC=CC=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ren L, Wang B, Gong K, Liu P, Zhou S, Zhang L, Xia X, Wang K. Epidemiology reveals Zhaotong City as the hub of human immunodeficiency virus type 1 transmission from the Yunnan province to other regions in China. J Gen Virol. 2017 Nov 1. doi: 10.1099/jgv.0.000961. [Epub ahead of print] PubMed PMID: 29091580.

2: Lu X, Kang X, Liu Y, Cui Z, Guo W, Zhao C, Li Y, Chen S, Li J, Zhang Y, Zhao H. HIV-1 molecular epidemiology among newly diagnosed HIV-1 individuals in Hebei, a low HIV prevalence province in China. PLoS One. 2017 Feb 8;12(2):e0171481. doi: 10.1371/journal.pone.0171481. eCollection 2017. PubMed PMID: 28178737; PubMed Central PMCID: PMC5298910.

3: Saenen ND, Vrijens K, Janssen BG, Madhloum N, Peusens M, Gyselaers W, Vanpoucke C, Lefebvre W, Roels HA, Nawrot TS. Placental Nitrosative Stress and Exposure to Ambient Air Pollution During Gestation: A Population Study. Am J Epidemiol. 2016 Sep 15;184(6):442-9. doi: 10.1093/aje/kww007. Epub 2016 Sep 5. PubMed PMID: 27601048.

4: Zhang Q, Gao M, Luo G, Han X, Bao W, Cheng Y, Tian W, Yan M, Yang G, An J. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407. doi: 10.1371/journal.pone.0152407. eCollection 2016. PubMed PMID: 27014877; PubMed Central PMCID: PMC4807779.

5: Silva AC, Oliveira MR, Amaral LF, Ferreira S, Garcia IR Jr, Mariano RC. Effect of Doxycycline in Gel Form on Bone Regeneration: Histomorphometric and Tomographic Study in Rat Calvaria. J Periodontol. 2016 Jan;87(1):74-82. doi: 10.1902/jop.2015.150343. Epub 2015 Aug 20. PubMed PMID: 26291295.

6: Nunes CC, Matte MC, Dias CF, Araújo LA, Guimarães LS, Almeida S, Brígido LF. The influence of HIV-1 subtypes C, CRF31_BC and B on disease progression and initial virologic response to HAART in a Southern Brazilian cohort. Rev Inst Med Trop Sao Paulo. 2014 May-Jun;56(3):205-11. PubMed PMID: 24878998; PubMed Central PMCID: PMC4085862.

7: Moradi M, Peyghan AA, Bagheri Z, Kamfiroozi M. Cation-π interaction of alkali metal ions with C24 fullerene: a DFT study. J Mol Model. 2012 Aug;18(8):3535-40. doi: 10.1007/s00894-012-1366-7. Epub 2012 Feb 11. PubMed PMID: 22327958.

8: Azevedo PS, Duarte DR, Minicucci MF, Matsubara BB, Matsubara LS, Novo R, Novelli EL, Campana AO, Paiva SA, Zornoff LA. Role of lipoperoxidation in the remodeling intensification induced by beta-carotene after infarction. Arq Bras Cardiol. 2009 Jul;93(1):34-8. English, Portuguese, Spanish. PubMed PMID: 19838468.

9: Zornoff LA, Matsubara BB, Matsubara LS, Azevedo PS, Minicucci MF, Campana AO, Paiva SA. Beta-carotene supplementation results in adverse ventricular remodeling after acute myocardial infarction. Nutrition. 2006 Feb;22(2):146-51. Epub 2005 Sep 23. PubMed PMID: 16183256.

10: Madersbacher S, Pycha A, Klingler CH, Mian C, Djavan B, Stulnig T, Marberger M. Interrelationships of bladder compliance with age, detrusor instability, and obstruction in elderly men with lower urinary tract symptoms. Neurourol Urodyn. 1999;18(1):3-15. PubMed PMID: 10090122.

11: Takeichi Y, Baba K, Kinouchi Y, Iida Y, Umeno Y, Muranishi S, Nakai Y. Combinative improving effect of increased solubility and the use of absorption enhancers on the rectal absorption of uracil in beagle dogs. Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2547-51. PubMed PMID: 2285989.