Okadaic Acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561543

CAS#: 78111-17-8

Description: Okadaic Acid is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. Okadaic Acid and its relatives are protein phosphatase inhibitors, specifically targeting protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A).

Chemical Structure

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Okadaic Acid
CAS# 78111-17-8
Instruction

Theoretical Analysis

MedKoo Cat#: 561543
Name: Okadaic Acid
CAS#: 78111-17-8
Chemical Formula: C44H68O13
Exact Mass: 804.47
Molecular Weight: 805.010
Elemental Analysis: C, 65.65; H, 8.51; O, 25.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Okadaic Acid;

IUPAC/Chemical Name: (R)-2-hydroxy-3-((2S,5R,6R,8S)-5-hydroxy-8-((R,E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-((1S,3S)-1-hydroxy-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-en-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-2-methylpropanoic acid

InChi Key: QNDVLZJODHBUFM-WFXQOWMNSA-N

InChi Code: InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1

SMILES Code: OC([C@](C)(O)C[C@]1([H])CC[C@@H](O)[C@@]2(O[C@@]([C@H](C)/C=C/[C@]3([H])O[C@]4(CC[C@](O[C@@]([C@@H](O)C[C@H](C)[C@@]5([H])O[C@@]6(CCCCO6)CC[C@H]5C)([H])C([C@H]7O)=C)([H])[C@@]7([H])O4)CC3)([H])CC(C)=C2)O1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 805.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Zimmer ER, Leuzy A, Souza DO, Portela LV. Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System. Mol Neurobiol. 2016 Aug;53(6):3753-3755. doi: 10.1007/s12035-015-9321-0. Epub 2015 Jul 4. Review. PubMed PMID: 26141124.

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10: Kamat PK, Rai S, Swarnkar S, Shukla R, Nath C. Molecular and cellular mechanism of okadaic acid (OKA)-induced neurotoxicity: a novel tool for Alzheimer's disease therapeutic application. Mol Neurobiol. 2014 Dec;50(3):852-65. doi: 10.1007/s12035-014-8699-4. Epub 2014 Apr 8. Review. PubMed PMID: 24710687.

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12: Valdiglesias V, Prego-Faraldo MV, Pásaro E, Méndez J, Laffon B. Okadaic acid: more than a diarrheic toxin. Mar Drugs. 2013 Oct 31;11(11):4328-49. doi: 10.3390/md11114328. Review. PubMed PMID: 24184795; PubMed Central PMCID: PMC3853731.

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