Daidzin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561538

CAS#: 552-66-9

Description: Daidzin is an aldehyde dehydrogenase 2 inhibitor. It decreases DNA damage but does not alter transmitter release by cisplatin. Daidzin is also an antidipsotropic agent, and shows potential for the treatment of alcohol dependency.


Price and Availability

Size
Price

10mg
USD 200
Size
Price

50mg
USD 475
Size
Price

100mg
USD 845

Daidzin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561538
Name: Daidzin
CAS#: 552-66-9
Chemical Formula: C21H20O9
Exact Mass: 416.1107
Molecular Weight: 416.382
Elemental Analysis: C, 60.58; H, 4.84; O, 34.58


Synonym: Daidzin; Daidzein 7-O-glucoside;

IUPAC/Chemical Name: 3-(4-Hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

InChi Key: KYQZWONCHDNPDP-QNDFHXLGSA-N

InChi Code: InChI=1S/C21H20O9/c22-8-16-18(25)19(26)20(27)21(30-16)29-12-5-6-13-15(7-12)28-9-14(17(13)24)10-1-3-11(23)4-2-10/h1-7,9,16,18-23,25-27H,8H2/t16-,18-,19+,20-,21-/m1/s1

SMILES Code: O=C1C(C2=CC=C(O)C=C2)=COC3=C1C=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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2: Rafii F. The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol. Metabolites. 2015 Jan 14;5(1):56-73. doi: 10.3390/metabo5010056. Review. PubMed PMID: 25594250; PubMed Central PMCID: PMC4381290.

3: Mattison DR, Karyakina N, Goodman M, LaKind JS. Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: a review of the data and identification of knowledge gaps. Crit Rev Toxicol. 2014 Sep;44(8):696-724. doi: 10.3109/10408444.2014.930813. Epub 2014 Aug 6. Review. PubMed PMID: 25099693.

4: Ozarowski M, Mikołajczak PŁ, Thiem B. [Medicinal plants in the phytotherapy of alcohol or nicotine addiction. Implication for plants in vitro cultures]. Przegl Lek. 2013;70(10):869-74. Review. Polish. PubMed PMID: 24501814.

5: Setchell KD, Clerici C. Equol: history, chemistry, and formation. J Nutr. 2010 Jul;140(7):1355S-62S. doi: 10.3945/jn.109.119776. Epub 2010 Jun 2. Review. PubMed PMID: 20519412; PubMed Central PMCID: PMC2884333.

6: Bolaños R, Del Castillo A, Francia J. Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. Menopause. 2010 May-Jun;17(3):660-6. Review. PubMed PMID: 20464785.

7: Lu L, Liu Y, Zhu W, Shi J, Liu Y, Ling W, Kosten TR. Traditional medicine in the treatment of drug addiction. Am J Drug Alcohol Abuse. 2009;35(1):1-11. doi: 10.1080/00952990802455469. Review. PubMed PMID: 19152199.

8: Nielsen IL, Williamson G. Review of the factors affecting bioavailability of soy isoflavones in humans. Nutr Cancer. 2007;57(1):1-10. Review. PubMed PMID: 17516857.

9: Tokunaga T. Novel physiological function of fructooligosaccharides. Biofactors. 2004;21(1-4):89-94. Review. PubMed PMID: 15630176.

10: Weisburger JH. Antimutagens, anticarcinogens, and effective worldwide cancer prevention. J Environ Pathol Toxicol Oncol. 1999;18(2):85-93. Review. PubMed PMID: 15281219.

11: Keung WM. Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence. Med Res Rev. 2003 Nov;23(6):669-96. Review. PubMed PMID: 12939789.

12: Rezvani AH, Overstreet DH, Perfumi M, Massi M. Plant derivatives in the treatment of alcohol dependency. Pharmacol Biochem Behav. 2003 Jun;75(3):593-606. Review. PubMed PMID: 12895677.

13: Sukmanskiĭ OI. [Isoflavones and calcified tissues]. Usp Fiziol Nauk. 2002 Apr-Jun;33(2):83-94. Review. Russian. PubMed PMID: 12004580.

14: Kinjo J. [Phytoestrogens]. Nihon Rinsho. 2000 Dec;58(12):2434-8. Review. Japanese. PubMed PMID: 11187733.

15: Lin RC, Li TK. Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Am J Clin Nutr. 1998 Dec;68(6 Suppl):1512S-1515S. Review. PubMed PMID: 9848526.

16: Lu LJ, Anderson KE. Sex and long-term soy diets affect the metabolism and excretion of soy isoflavones in humans. Am J Clin Nutr. 1998 Dec;68(6 Suppl):1500S-1504S. Review. PubMed PMID: 9848524.

17: Keung WM, Vallee BL. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry. 1998 Feb;47(4):499-506. Review. PubMed PMID: 9461670.