M7594_0037

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561528

CAS#: 774551-07-4

Description: M7594_0037 is a small molecule inhibitor of human peptide deformylase (HsPDF). HsPDF is an important target for anticancer drug discovery. M7594_0037 exhibits potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 35.26, 29.63 and 24.63 μM, respectively.


Price and Availability

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M7594_0037 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561528
Name: M7594_0037
CAS#: 774551-07-4
Chemical Formula: C20H22ClN3O3
Exact Mass: 387.135
Molecular Weight: 387.86
Elemental Analysis: C, 61.93; H, 5.72; Cl, 9.14; N, 10.83; O, 12.37


Synonym: M7594_0037; M7594-0037; M7594 0037; M75940037;

IUPAC/Chemical Name: 2-[2-Chloro-4-({[2-(1H-indol-3-yl)ethyl]amino}methyl)-6-methoxyphenoxy]acetamide

InChi Key: WGLLOUBILAXFSI-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22ClN3O3/c1-26-18-9-13(8-16(21)20(18)27-12-19(22)25)10-23-7-6-14-11-24-17-5-3-2-4-15(14)17/h2-5,8-9,11,23-24H,6-7,10,12H2,1H3,(H2,22,25)

SMILES Code: O=C(N)COC1=C(OC)C=C(CNCCC2=CNC3=C2C=CC=C3)C=C1Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gao J, Wang T, Qiu S, Zhu Y, Liang L, Zheng Y. Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer. Molecules. 2016 Mar 23;21(4):396. doi: 10.3390/molecules21040396. PubMed PMID: 27023495.