WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571353
Description: ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation. It causes osteoclast apoptosis without effects of biphosphonates such as bone formation inhibition and anabolism of PTH. ABD-350 has potent antiresorptive effects in vitro and in vivo that do not adversely affect osteoblast function. ABD350 prevented ovariectomy-induced bone loss.
MedKoo Cat#: 571353
Chemical Formula: C19H22F2O2
Exact Mass: 320.1588
Molecular Weight: 320.38
Elemental Analysis: C, 71.23; H, 6.92; F, 11.86; O, 9.99
Synonym: ABD-350; ABD350; ABD 350
IUPAC/Chemical Name: 1,6-Hexanediol, 1-(2',4'-difluoro-2-methyl(1,1'-biphenyl)-4-yl)-
InChi Key: MLHURYYXRZMSBS-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H22F2O2/c1-13-11-14(19(23)5-3-2-4-10-22)6-8-16(13)17-9-7-15(20)12-18(17)21/h6-9,11-12,19,22-23H,2-5,10H2,1H3
SMILES Code: OC(C1=CC=C(C2=CC=C(F)C=C2F)C(C)=C1)CCCCCO
1: Idris AI, Greig IR, Bassonga-Landao E, Ralston SH, van 't Hof RJ. Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation. Endocrinology. 2009 Jan;150(1):5-13. doi: 10.1210/en.2008-0998. Epub 2008 Sep 4. PubMed PMID: 18772231.