CaMKII-IN-1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581018

CAS#: 1208123-85-6

Description: CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.


Price and Availability

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CaMKII-IN-1, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581018
Name: CaMKII-IN-1
CAS#: 1208123-85-6
Chemical Formula: C29H30ClN5O2S
Exact Mass: 547.1809
Molecular Weight: 548.1
Elemental Analysis: C, 63.55; H, 5.52; Cl, 6.47; N, 12.78; O, 5.84; S, 5.85


Synonym: CaMKII-IN-1; CaMKII; CaMKII IN-1; CaMKII IN 1; CaMKII-IN 1.

IUPAC/Chemical Name: N-[6-Benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-3-chloro-2-methylbenzenesulfonamide

InChi Key: LGUUETDTMQTHML-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H30ClN5O2S/c1-21-25(30)13-8-14-27(21)38(36,37)34-28-24-20-35(19-23-11-6-3-7-12-23)18-16-26(24)32-29(33-28)31-17-15-22-9-4-2-5-10-22/h2-14H,15-20H2,1H3,(H2,31,32,33,34)

SMILES Code: O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Li DP, Zhou JJ, Zhang J, Pan HL. CaMKII Regulates Synaptic NMDA Receptor
Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in
Hypertension. J Neurosci. 2017 Oct 2. pii: 2141-17. doi:
10.1523/JNEUROSCI.2141-17.2017. [Epub ahead of print] PubMed PMID: 28972129.

2: Chen W, An P, Quan XJ, Zhang J, Zhou ZY, Zou LP, Luo HS.
Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer
proliferation and migration via ERK1/2 and p38 pathways. World J Gastroenterol.
2017 Sep 7;23(33):6111-6118. doi: 10.3748/wjg.v23.i33.6111. PubMed PMID:
28970726; PubMed Central PMCID: PMC5597502.

3: Joseph JS, Ayeleso AO, Mukwevho E. Role of exercise-induced calmodulin protein
kinase (CAMK)II activation in the regulation of omega-6 fatty acids and lipid
metabolism genes in rat skeletal muscle. Physiol Res. 2017 Sep 22. [Epub ahead of
print] PubMed PMID: 28937250.

4: Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q, Hu G.
Differential effects on lung and bone metastasis of breast cancer by Wnt
signalling inhibitor DKK1. Nat Cell Biol. 2017 Oct;19(10):1274-1285. doi:
10.1038/ncb3613. Epub 2017 Sep 11. PubMed PMID: 28892080.

5: Burgos JI, Yeves AM, Barrena JP, Portiansky EL, Vila-Petroff MG, Ennis IL.
Nitric oxide and CaMKII: Critical steps in the cardiac contractile response To
IGF-1 and swim training. J Mol Cell Cardiol. 2017 Sep 1;112:16-26. doi:
10.1016/j.yjmcc.2017.08.014. [Epub ahead of print] PubMed PMID: 28867536.

6: Tsai CY, Kuo WW, Shibu MA, Lin YM, Liu CN, Chen YH, Day CH, Shen CY,
Viswanadha VP, Huang CY. E2/ER β inhibit ISO-induced cardiac cellular hypertrophy
by suppressing Ca2+-calcineurin signaling. PLoS One. 2017 Sep 1;12(9):e0184153.
doi: 10.1371/journal.pone.0184153. eCollection 2017. PubMed PMID: 28863192;
PubMed Central PMCID: PMC5580914.

7: Li J, Tang B, Zhang W, Wang C, Yang S, Zhang B, Gao X. Relationship and
mechanism of Kv2.1 expression to ADH secretion in rats with heart failure. Am J
Transl Res. 2017 Aug 15;9(8):3687-3695. eCollection 2017. PubMed PMID: 28861159;
PubMed Central PMCID: PMC5575182.

8: Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela
A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M,
Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D. Impaired calcium
homeostasis is associated with sudden cardiac death and arrhythmias in a genetic
equivalent mouse model of the human HRC-Ser96Ala variant. Cardiovasc Res. 2017
Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113. PubMed PMID: 28859293.

9: Ge L, Wang Z, Li C, Zhang Y, Chen L. Suppression of oxidative stress and
apoptosis in electrically stimulated neonatal rat cardiomyocytes by resveratrol
and underlying mechanisms. J Cardiovasc Pharmacol. 2017 Aug 18. doi:
10.1097/FJC.0000000000000534. [Epub ahead of print] PubMed PMID: 28857948.

10: Wang R, Yin YX, Mahmood Q, Wang XJ, Gao YP, Gou GJ, Ahmed MM, Kohji F, Du YZ,
Han F. Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting
nitrosative stress and NLRP3 signaling in mice with bilateral carotid artery
stenosis. CNS Neurosci Ther. 2017 Oct;23(10):818-826. doi: 10.1111/cns.12726.
Epub 2017 Aug 28. PubMed PMID: 28851042.

11: Chen Y, Yuan J, Jiang G, Zhu J, Zou Y, Lv Q. Lercanidipine attenuates
angiotensin II-induced cardiomyocyte hypertrophy by blocking calcineurin-NFAT3
and CaMKII-HDAC4 signaling. Mol Med Rep. 2017 Oct;16(4):4545-4552. doi:
10.3892/mmr.2017.7211. Epub 2017 Aug 10. PubMed PMID: 28849081.

12: Espejo MS, Aiello I, Sepúlveda M, Vila Petroff MG, Aiello EA, De Giusti VC.
The reduced myofilament responsiveness to calcium contributes to the negative
force-frequency relationship in rat cardiomyocytes: role of reactive oxygen
species and p-38 map kinase. Pflugers Arch. 2017 Aug 23. doi:
10.1007/s00424-017-2058-z. [Epub ahead of print] PubMed PMID: 28836001.

13: Andrei SR, Ghosh M, Sinharoy P, Dey S, Bratz IN, Damron DS. TRPA1 ion channel
stimulation enhances cardiomyocyte contractile function via a CaMKII-dependent
pathway. Channels (Austin). 2017 Aug 9:1-17. doi: 10.1080/19336950.2017.1365206.
[Epub ahead of print] PubMed PMID: 28792844.

14: Dai H, Jia G, Wang H, Yang J, Jiang H, Chu M. Epidermal growth factor
receptor transactivation is involved in the induction of human hepatoma SMMC7721
cell proliferation by insufficient radiofrequency ablation. Oncol Lett. 2017
Aug;14(2):2463-2467. doi: 10.3892/ol.2017.6463. Epub 2017 Jun 22. PubMed PMID:
28789459; PubMed Central PMCID: PMC5530000.

15: Jiang S, Huo D, Wang X, Zhao H, Tan J, Zeng Q, OʼRourke ST, Sun C.
β-adrenergic Receptor-stimulated Cardiac Myocyte Apoptosis: Role of Cytochrome
P450 ω-hydroxylase. J Cardiovasc Pharmacol. 2017 Aug;70(2):94-101. doi:
10.1097/FJC.0000000000000499. PubMed PMID: 28768289.

16: Groen C, Bähring R. Modulation of human Kv4.3/KChIP2 channel inactivation
kinetics by cytoplasmic Ca²⁺. Pflugers Arch. 2017 Jul 22. doi:
10.1007/s00424-017-2039-2. [Epub ahead of print] PubMed PMID: 28735419.

17: Liao Q, Zhang R, Wang X, Nian W, Ke L, Ouyang W, Zhang Z. Effect of fluoride
exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis
regulators in PC12 cells. Environ Toxicol Pharmacol. 2017 Sep;54:74-79. doi:
10.1016/j.etap.2017.06.018. Epub 2017 Jun 30. PubMed PMID: 28697452.

18: Gu Y, Zhang J, Ma X, Kim BW, Wang H, Li J, Pan Y, Xu Y, Ding L, Yang L, Guo
C, Wu X, Wu J, Wu K, Gan X, Li G, Li L, Forman SJ, Chan WC, Xu R, Huang W.
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma. Cancer
Cell. 2017 Jul 10;32(1):115-128.e7. doi: 10.1016/j.ccell.2017.06.001. PubMed
PMID: 28697340; PubMed Central PMCID: PMC5552197.

19: Wang H, Do DC, Liu J, Wang B, Qu J, Ke X, Luo X, Tang HM, Tang HL, Hu C,
Anderson ME, Liu Z, Gao P. Functional role of kynurenine and aryl hydrocarbon
receptor axis in chronic rhinosinusitis with nasal polyps. J Allergy Clin
Immunol. 2017 Jul 6. pii: S0091-6749(17)31085-0. doi: 10.1016/j.jaci.2017.06.013.
[Epub ahead of print] PubMed PMID: 28689792.

20: Zhong P, Quan D, Huang Y, Huang H. CaMKII Activation Promotes Cardiac
Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in
High-fat Diet-Fed Mice With Hyperlipidemia Conditions. J Cardiovasc Pharmacol.
2017 Oct;70(4):245-254. doi: 10.1097/FJC.0000000000000512. PubMed PMID: 28662005.