ABD56

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571350

CAS#: 521294-19-9

Description: ABD56 is a biochemical that inhibits osteoclast formation and activity in vitro and in vivo. ABD56 causes osteoclast apoptosis through an unknown method, which is most likely inhibition of survival signals such as ERK and NFkappaB, rather than activation of the p38 or Jnk MAPK pathways.


Price and Availability

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ABD56 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571350
Name: ABD56
CAS#: 521294-19-9
Chemical Formula: C17H18O3
Exact Mass: 270.1256
Molecular Weight: 270.33
Elemental Analysis: C, 75.53; H, 6.71; O, 17.76


Synonym: ABD56; ABD-56; ABD 56

IUPAC/Chemical Name: (1,1'-Biphenyl)-4-carboxylic acid, 4-hydroxybutyl ester

InChi Key: ODVRBGUFYYVDEP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18O3/c18-12-4-5-13-20-17(19)16-10-8-15(9-11-16)14-6-2-1-3-7-14/h1-3,6-11,18H,4-5,12-13H2

SMILES Code: O=C(C1=CC=C(C2=CC=CC=C2)C=C1)OCCCCO


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Idris AI, Mrak E, Greig I, Guidobono F, Ralston SH, van 't Hof R. ABD56 causes osteoclast apoptosis by inhibiting the NFkappaB and ERK pathways. Biochem Biophys Res Commun. 2008 Jun 20;371(1):94-8. doi: 10.1016/j.bbrc.2008.04.014. Epub 2008 Apr 14. Erratum in: Biochem Biophys Res Commun. 2010 Apr 30;395(2):289. Idris, Aymen [corrected to Idris, Aymen I]. PubMed PMID: 18413146.

2: Idris AI, Greig IR, Bassonga-Landao E, Ralston SH, van 't Hof RJ. Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation. Endocrinology. 2009 Jan;150(1):5-13. doi: 10.1210/en.2008-0998. Epub 2008 Sep 4. PubMed PMID: 18772231.