BKM1740

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561519

CAS#: 1070966-97-0

Description: BKM1740 is an inhibitor of survivin expression at both the mRNA and protein levels in vitro. BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin.

Chemical Structure

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BKM1740
CAS# 1070966-97-0
Instruction

Theoretical Analysis

MedKoo Cat#: 561519
Name: BKM1740
CAS#: 1070966-97-0
Chemical Formula: C39H46Cl2F5N3O9P2
Exact Mass: 927.20
Molecular Weight: 928.640
Elemental Analysis: C, 50.44; H, 4.99; Cl, 7.63; F, 10.23; N, 4.52; O, 15.51; P, 6.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BKM1740; BKM-1740; BKM 1740;

IUPAC/Chemical Name: tetraethyl ((4-(3-(4-((2,6-dichlorobenzyl)oxy)phenyl)-2-(3-(perfluorophenyl)acrylamido)propanamido)piperidin-1-yl)methylene)(S,E)-bis(phosphonate)

InChi Key: MJDJHVSCDMJYOU-XCXBIEIDSA-N

InChi Code: InChI=1S/C39H46Cl2F5N3O9P2/c1-5-55-59(52,56-6-2)39(60(53,57-7-3)58-8-4)49-20-18-25(19-21-49)47-38(51)31(48-32(50)17-16-27-33(42)35(44)37(46)36(45)34(27)43)22-24-12-14-26(15-13-24)54-23-28-29(40)10-9-11-30(28)41/h9-17,25,31,39H,5-8,18-23H2,1-4H3,(H,47,51)(H,48,50)/b17-16+/t31-/m0/s1

SMILES Code: O=C([C@H](CC1=CC=C(OCC2=C(Cl)C=CC=C2Cl)C=C1)NC(/C=C/C3=C(F)C(F)=C(F)C(F)=C3F)=O)NC4CCN(C(P(OCC)(OCC)=O)P(OCC)(OCC)=O)CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 928.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Seo SI, Gera L, Zhau HE, Qian WP, Iqbal S, Johnson NA, Zhang S, Zayzafoon M, Stewart J, Wang R, Chung LW, Wu D. BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis. Clin Cancer Res. 2008 Oct 1;14(19):6198-206. doi: 10.1158/1078-0432.CCR-08-1023. PubMed PMID: 18829499.