E1R

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561517

CAS#: 1301211-78-8

Description: E1R is a novel positive allosteric modulator of sigma-1 receptors. E1R is a novel 4,5-disubstituted derivative of piracetam that enhances cognition and demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice.


Price and Availability

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E1R is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561517
Name: E1R
CAS#: 1301211-78-8
Chemical Formula: C13H16N2O2
Exact Mass: 232.1212
Molecular Weight: 232.28
Elemental Analysis: C, 67.22; H, 6.94; N, 12.06; O, 13.78


Synonym: E1R; E-1-R; E 1 R;

IUPAC/Chemical Name: (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide

InChi Key: ZTGRWYMPQCQTHD-ONGXEEELSA-N

InChi Code: InChI=1S/C13H16N2O2/c1-9-11(10-5-3-2-4-6-10)7-13(17)15(9)8-12(14)16/h2-6,9,11H,7-8H2,1H3,(H2,14,16)/t9-,11-/m0/s1

SMILES Code: O=C(N)CN1C(C[C@H](C2=CC=CC=C2)[C@@H]1C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Saulite L, Vavers E, Zvejniece L, Dambrova M, Riekstina U. The Differentiation of Skin Mesenchymal Stem Cells Towards a Schwann Cell Phenotype: Impact of Sigma-1 Receptor Activation. Mol Neurobiol. 2017 Apr 28. doi: 10.1007/s12035-017-0511-9. [Epub ahead of print] PubMed PMID: 28455697.

2: Vavers E, Svalbe B, Lauberte L, Stonans I, Misane I, Dambrova M, Zvejniece L. The activity of selective sigma-1 receptor ligands in seizure models in vivo. Behav Brain Res. 2017 Jun 15;328:13-18. doi: 10.1016/j.bbr.2017.04.008. Epub 2017 Apr 4. PubMed PMID: 28389336.

3: Zvejniece L, Vavers E, Svalbe B, Vilskersts R, Domracheva I, Vorona M, Veinberg G, Misane I, Stonans I, Kalvinsh I, Dambrova M. The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. Br J Pharmacol. 2014 Feb;171(3):761-71. doi: 10.1111/bph.12506. PubMed PMID: 24490863; PubMed Central PMCID: PMC3969087.