K67
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581005

CAS#: 2046250-48-8

Description: K67 is a specific inhibitor against the interaction between KEAP1 DC domain and S349-phosphorylated KIR of p62/SQSTM1, K67 effectively inhibits the proliferation of HCC cultures with high cellular p62 S351-phosphorylation by restoring KEAP1-driven NRF2 ubiquitination and degradation.


Price and Availability

Size
Price

5mg
USD 250
Size
Price

25mg
USD 650
Size
Price

K67, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 581005
Name: K67
CAS#: 2046250-48-8
Chemical Formula: C29H30N2O7S2
Exact Mass: 582.1494
Molecular Weight: 582.68
Elemental Analysis: C, 59.78; H, 5.19; N, 4.81; O, 19.22; S, 11.00


Synonym: K67; K 67; K-67.

IUPAC/Chemical Name: 2-Acetonyl-1,4-bis[(4-ethoxybenzensulfonyl)amino]naphthalene

InChi Key: VUIVGOOWLHGDPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H30N2O7S2/c1-4-37-22-10-14-24(15-11-22)39(33,34)30-28-19-21(18-20(3)32)29(27-9-7-6-8-26(27)28)31-40(35,36)25-16-12-23(13-17-25)38-5-2/h6-17,19,30-31H,4-5,18H2,1-3H3

SMILES Code: O=S(NC1=C2C=CC=CC2=C(NS(=O)(C3=CC=C(OCC)C=C3)=O)C(CC(C)=O)=C1)(C4=CC=C(OCC)C=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Batool M, Shah M, Patra MC, Yesudhas D, Choi S. Structural insights into the Middle East respiratory syndrome coronavirus 4a protein and its dsRNA binding mechanism. Sci Rep. 2017 Sep 12;7(1):11362. doi: 10.1038/s41598-017-11736-6. PubMed PMID: 28900197; PubMed Central PMCID: PMC5596018.

2: Panzuto F, Cicchese N, Partelli S, Rinzivillo M, Capurso G, Merola E, Manzoni M, Pucci E, Iannicelli E, Pilozzi E, Rossi M, Doglioni C, Falconi M, Delle Fave G. Impact of Ki67 re-assessment at time of disease progression in patients with pancreatic neuroendocrine neoplasms. PLoS One. 2017 Jun 23;12(6):e0179445. doi: 10.1371/journal.pone.0179445. eCollection 2017. PubMed PMID: 28644861; PubMed Central PMCID: PMC5482443.

3: Hu W, Coomer TD, Loka DA, Oosterhuis DM, Zhou Z. Potassium deficiency affects the carbon-nitrogen balance in cotton leaves. Plant Physiol Biochem. 2017 Jun;115:408-417. doi: 10.1016/j.plaphy.2017.04.005. Epub 2017 Apr 6. PubMed PMID: 28441628.

4: Zhang H, Li M, Li J, Wang G, Li F, Xu D, Liu Y, Xiong M. A key esterase required for the mineralization of quizalofop-p-ethyl by a natural consortium of Rhodococcus sp. JT-3 and Brevundimonas sp. JT-9. J Hazard Mater. 2017 Apr 5;327:1-10. doi: 10.1016/j.jhazmat.2016.12.038. Epub 2016 Dec 21. PubMed PMID: 28027504.

5: Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T. Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5956-5959. doi: 10.1016/j.bmcl.2016.10.083. Epub 2016 Oct 27. PubMed PMID: 27839920.

6: Murray D. Is it time to abandon suicide risk assessment? BJPsych Open. 2016 Feb 18;2(1):e1-e2. eCollection 2016 Jan. PubMed PMID: 27703761; PubMed Central PMCID: PMC4998936.

7: Restrepo-Coupe N, Levine NM, Christoffersen BO, Albert LP, Wu J, Costa MH, Galbraith D, Imbuzeiro H, Martins G, da Araujo AC, Malhi YS, Zeng X, Moorcroft P, Saleska SR. Do dynamic global vegetation models capture the seasonality of carbon fluxes in the Amazon basin? A data-model intercomparison. Glob Chang Biol. 2017 Jan;23(1):191-208. doi: 10.1111/gcb.13442. Epub 2016 Aug 29. PubMed PMID: 27436068.

8: Huang G, Chen S, Wang D, Wang R, Lin L, Chen S, Wang L, Huang Q. High Ki67 Expression has Prognostic Value in Surgically-Resected T3 Gastric Adenocarcinoma. Clin Lab. 2016;62(1-2):141-53. PubMed PMID: 27012044.

9: Mohamed MA, Shehata MA, Rafeek E. Virulence Genes Content and Antimicrobial Resistance in Escherichia coli from Broiler Chickens. Vet Med Int. 2014;2014:195189. doi: 10.1155/2014/195189. Epub 2014 Nov 24. PubMed PMID: 25506467; PubMed Central PMCID: PMC4259055.

10: Tran TN, Kosaraju MG, Tamamizu-Kato S, Akintunde O, Zheng Y, Bielicki JK, Pinkerton K, Uchida K, Lee YY, Narayanaswami V. Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry. Biochemistry. 2014 Jan 21;53(2):361-75. doi: 10.1021/bi401404u. Epub 2014 Jan 8. PubMed PMID: 24325674; PubMed Central PMCID: PMC3937454.

11: Wheaton AG, Ford ES, Thompson WW, Greenlund KJ, Presley-Cantrell LR, Croft JB. Pulmonary function, chronic respiratory symptoms, and health-related quality of life among adults in the United States--National Health and Nutrition Examination Survey 2007-2010. BMC Public Health. 2013 Sep 17;13:854. doi: 10.1186/1471-2458-13-854. PubMed PMID: 24040892; PubMed Central PMCID: PMC3848467.

12: Zhang X, Onufrak S, Holt JB, Croft JB. A multilevel approach to estimating small area childhood obesity prevalence at the census block-group level. Prev Chronic Dis. 2013 May 2;10:E68. doi: 10.5888/pcd10.120252. PubMed PMID: 23639763; PubMed Central PMCID: PMC3652721.

13: Ford ES, Croft JB, Posner SF, Goodman RA, Giles WH. Co-occurrence of leading lifestyle-related chronic conditions among adults in the United States, 2002-2009. Prev Chronic Dis. 2013 Apr 25;10:E60. doi: 10.5888/pcd10.120316. PubMed PMID: 23618540; PubMed Central PMCID: PMC3652715.

14: Zhukovsky MA, Lee PH, Ott A, Helms V. Putative cholesterol-binding sites in human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5. Proteins. 2013 Apr;81(4):555-67. doi: 10.1002/prot.24211. Epub 2012 Dec 24. PubMed PMID: 23161741.

15: Li S, Wang M, Ao X, Chang AK, Yang C, Zhao F, Bi H, Liu Y, Xiao L, Wu H. CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α. Oncogene. 2013 Oct 10;32(41):4883-91. doi: 10.1038/onc.2012.518. Epub 2012 Nov 19. PubMed PMID: 23160374.

16: Ford ES, Greenlund KJ, Hong Y. Ideal cardiovascular health and mortality from all causes and diseases of the circulatory system among adults in the United States. Circulation. 2012 Feb 28;125(8):987-95. doi: 10.1161/CIRCULATIONAHA.111.049122. Epub 2012 Jan 30. PubMed PMID: 22291126; PubMed Central PMCID: PMC4556343.

17: Cappadocia L, Parent JS, Zampini E, Lepage E, Sygusch J, Brisson N. A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Res. 2012 Jan;40(1):258-69. doi: 10.1093/nar/gkr740. Epub 2011 Sep 12. PubMed PMID: 21911368; PubMed Central PMCID: PMC3245945.

18: Zhao G, Ford ES, Tsai J, Li C, Croft JB. Low concentrations of serum 25-hydroxyvitamin D associated with increased risk for chronic bronchitis among US adults. Br J Nutr. 2012 May;107(9):1386-92. doi: 10.1017/S0007114511004417. Epub 2011 Sep 8. PubMed PMID: 21899806.

19: Tsai J, Ford ES, Zhao G, Li C, Greenlund KJ, Croft JB. Co-occurrence of obesity and patterns of alcohol use associated with elevated serum hepatic enzymes in US adults. J Behav Med. 2012 Apr;35(2):200-10. doi: 10.1007/s10865-011-9353-5. Epub 2011 May 28. PubMed PMID: 21626151.

20: Edvinsson JM, Shah AJ, Palmer LG. Kir4.1 K+ channels are regulated by external cations. Channels (Austin). 2011 May-Jun;5(3):269-79. Epub 2011 May 1. PubMed PMID: 21532341; PubMed Central PMCID: PMC3225756.