Gamithromycin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329858

CAS#: 145435-72-9

Description: Gamithromycin is an animal used antibiotics. Gamithromycin is active in vitro against the bacterial agents most commonly associated with bronchopneumonia in older foals.


Price and Availability

Size
Price

25mg
USD 650
Size
Price

Size
Price

Gamithromycin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329858
Name: Gamithromycin
CAS#: 145435-72-9
Chemical Formula: C40H76N2O12
Exact Mass: 776.5398
Molecular Weight: 777.05
Elemental Analysis: C, 61.83; H, 9.86; N, 3.61; O, 24.71


Synonym: Gamithromycin; GAM,

IUPAC/Chemical Name: (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one

SMILES Code: O=C1[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hildebrand F, Venner M, Giguère S. Efficacy of gamithromycin for the treatment of foals with mild to moderate bronchopneumonia. J Vet Intern Med. 2015 Jan;29(1):333-8. doi: 10.1111/jvim.12504. PubMed PMID: 25619521; PubMed Central PMCID: PMC4858060.

2: Kellermann M, Huang RA, Forbes AB, Rehbein S. Gamithromycin plasma and skin pharmacokinetics in sheep. Res Vet Sci. 2014 Oct;97(2):199-203. doi: 10.1016/j.rvsc.2014.08.008. Epub 2014 Sep 4. PubMed PMID: 25241389.

3: Mitchell JD, Goh S, McKellar QA, McKeever DJ. In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony. Vet J. 2013 Sep;197(3):806-11. doi: 10.1016/j.tvjl.2013.05.025. Epub 2013 Jun 28. PubMed PMID: 23810743.

4: Watteyn A, Plessers E, Wyns H, De Baere S, De Backer P, Croubels S. Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens. Poult Sci. 2013 Jun;92(6):1516-22. doi: 10.3382/ps.2012-02932. PubMed PMID: 23687147.

5: Berghaus LJ, Giguère S, Sturgill TL, Bade D, Malinski TJ, Huang R. Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals. J Vet Pharmacol Ther. 2012 Feb;35(1):59-66. doi: 10.1111/j.1365-2885.2011.01292.x. Epub 2011 Mar 28. PubMed PMID: 21443748.

6: Torres S, Thomson DU, Bello NM, Nosky BJ, Reinhardt CD. Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease. Am J Vet Res. 2013 Jun;74(6):839-46. doi: 10.2460/ajvr.74.6.839. PubMed PMID: 23718651.

7: DeDonder KD, Apley MD, Li M, Gehring R, Harhay DM, Lubbers BV, White BJ, Capik SF, KuKanich B, Riviere JE, Tessman RK. Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multisource commingled feedlot cattle. J Vet Pharmacol Ther. 2016 Apr;39(2):157-66. doi: 10.1111/jvp.12267. Epub 2015 Oct 6. PubMed PMID: 26441021.

8: Strobel H, Lauseker M, Forbes AB. Targeted antibiotic treatment of lame sheep with footrot using either oxytetracycline or gamithromycin. Vet Rec. 2014 Jan 11;174(2):46. doi: 10.1136/vr.101840. Epub 2013 Dec 20. PubMed PMID: 24362004.

9: Wyns H, Meyer E, Plessers E, Watteyn A, van Bergen T, Schauvliege S, De Baere S, Devreese M, De Backer P, Croubels S. Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation. Vet Immunol Immunopathol. 2015 Dec 15;168(3-4):211-22. doi: 10.1016/j.vetimm.2015.09.014. Epub 2015 Sep 28. PubMed PMID: 26547885.

10: Torres S, Thomson DU, Bello NM, Nosky BJ, Reinhardt CD. Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves. Am J Vet Res. 2013 Jun;74(6):847-53. doi: 10.2460/ajvr.74.6.847. PubMed PMID: 23718652.

11: Wyns H, Meyer E, Plessers E, Watteyn A, De Baere S, De Backer P, Croubels S. Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in pigs. Res Vet Sci. 2014 Feb;96(1):160-3. doi: 10.1016/j.rvsc.2013.11.012. Epub 2013 Dec 1. PubMed PMID: 24331716.

12: Forbes AB, Strobel H, Stamphoj I. Field studies on the elimination of footrot in sheep through whole flock treatments with gamithromycin. Vet Rec. 2014 Feb 8;174(6):146. doi: 10.1136/vr.102028. Epub 2014 Jan 29. PubMed PMID: 24477473.

13: Giguère S, Huang R, Malinski TJ, Dorr PM, Tessman RK, Somerville BA. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells, and lung tissue in cattle. Am J Vet Res. 2011 Mar;72(3):326-30. doi: 10.2460/ajvr.72.3.326. PubMed PMID: 21355734.

14: Jones ML, Washburn KE, Fajt VR, Rice S, Coetzee JF. Synovial fluid pharmacokinetics of tulathromycin, gamithromycin and florfenicol after a single subcutaneous dose in cattle. BMC Vet Res. 2015 Feb 7;11:26. doi: 10.1186/s12917-015-0346-4. PubMed PMID: 25886555; PubMed Central PMCID: PMC4332912.

15: Plessers E, Watteyn A, Wyns H, Pardon B, De Backer P, Croubels S. Study of the immunomodulatory properties of gamithromycin and dexamethasone in a lipopolysaccharide inflammation model in calves. Res Vet Sci. 2015 Dec;103:218-23. doi: 10.1016/j.rvsc.2015.10.014. Epub 2015 Oct 28. PubMed PMID: 26679821.

16: Watteyn A, Devreese M, De Baere S, Wyns H, Plessers E, Boyen F, Haesebrouck F, De Backer P, Croubels S. Pharmacokinetic and pharmacodynamic properties of gamithromycin in turkey poults with respect to Ornithobacterium rhinotracheale. Poult Sci. 2015 Sep;94(9):2066-74. doi: 10.3382/ps/pev217. Epub 2015 Jul 20. PubMed PMID: 26195808.

17: Huang RA, Letendre LT, Banav N, Fischer J, Somerville B. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010 Jun 1;33(3):227-37. doi: 10.1111/j.1365-2885.2009.01125.x. Erratum in: J Vet Pharmacol Ther. 2010 Dec;33(6):622. PubMed PMID: 20557439.

18: De Baere S, Devreese M, Watteyn A, Wyns H, Plessers E, De Backer P, Croubels S. Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitative determination of gamithromycin in animal plasma, lung tissue and pulmonary epithelial lining fluid. J Chromatogr A. 2015 Jun 12;1398:73-82. doi: 10.1016/j.chroma.2015.04.022. Epub 2015 Apr 17. PubMed PMID: 25937131.

19: Plessers E, Wyns H, Watteyn A, Pardon B, De Baere S, Sys SU, De Backer P, Croubels S. Immunomodulatory properties of gamithromycin and ketoprofen in lipopolysaccharide-challenged calves with emphasis on the acute-phase response. Vet Immunol Immunopathol. 2016 Mar;171:28-37. doi: 10.1016/j.vetimm.2016.01.007. Epub 2016 Jan 29. PubMed PMID: 26964715.

20: Forbes AB, Ramage C, Sales J, Baggott D, Donachie W. Determination of the duration of antibacterial efficacy following administration of gamithromycin using a bovine Mannheimia haemolytica challenge model. Antimicrob Agents Chemother. 2011 Feb;55(2):831-5. doi: 10.1128/AAC.00552-10. Epub 2010 Nov 15. PubMed PMID: 21078926; PubMed Central PMCID: PMC3028799.