Galanthaminone
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329851

CAS#: 510-77-0

Description: Galanthaminone is a cholinesterase (AChE) inhibitor for the treatment of mild to moderate Alzheimer's disease.


Price and Availability

Size
Price

5mg
USD 385
Size
Price

Size
Price

Galanthaminone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329851
Name: Galanthaminone
CAS#: 510-77-0
Chemical Formula: C17H19NO3
Exact Mass: 285.136
Molecular Weight: 285.343
Elemental Analysis: C, 71.56; H, 6.71; N, 4.91; O, 16.82


Synonym: Galanthaminone; (-)-Narwedine; Narwedine; 3-Deoxy-3-oxo-galanthamine;

IUPAC/Chemical Name: (4aS,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one

InChi Key: QENVUHCAYXAROT-YOEHRIQHSA-N

InChi Code: InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m0/s1

SMILES Code: O=C1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bickel U, Thomsen T, Weber W, Fischer JP, Bachus R, Nitz M, Kewitz H.
Pharmacokinetics of galanthamine in humans and corresponding cholinesterase
inhibition. Clin Pharmacol Ther. 1991 Oct;50(4):420-8. PubMed PMID: 1914378.

2: Thomsen T, Bickel U, Fischer JP, Kewitz H. Stereoselectivity of cholinesterase
inhibition by galanthamine and tolerance in humans. Eur J Clin Pharmacol.
1990;39(6):603-5. PubMed PMID: 2095347.

3: Mihailova D, Yamboliev I, Zhivkova Z, Tencheva J, Jovovich V. Pharmacokinetics
of galanthamine hydrobromide after single subcutaneous and oral dosage in humans.
Pharmacology. 1989;39(1):50-8. PubMed PMID: 2587617.

4: Mihailova D, Velkov M, Zhivkova Z. In vitro metabolism of galanthamine
hydrobromide (Nivalin) by rat and rabbit liver homogenate. Eur J Drug Metab
Pharmacokinet. 1987 Jan-Mar;12(1):25-30. PubMed PMID: 3609070.

5: KOIZUMI J, KOBAYASHI S, UYEO S. GALANTHAMINE CHEMISTRY. V. FORMATION OF
HYDROXYAPOGALANTHAMINE FROM GALANTHAMINONE AND THE SYNTHESIS OF ITS TRIMETHYL
ETHER. Chem Pharm Bull (Tokyo). 1964 Jun;12:696-705. PubMed PMID: 14199166.