Mabuterol free base
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329850

CAS#: 56341-08-3 (free base)

Description: Mabuterol is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6) g/ml. Mabuterol was 3 times more potent in relaxing the isolated rat uterus, but 700 times less potent than isoprenaline in relaxing the rabbit jejunum. Mabuterol (p.o.) depressed the intestinal propulsion and was equipotent to isoprenaline and 2.5 times less potent than salbutamol.


Price and Availability

Size
Price

5mg
USD 245
Size
Price

10mg
USD 375
Size
Price

Mabuterol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329850
Name: Mabuterol free base
CAS#: 56341-08-3 (free base)
Chemical Formula: C13H18ClF3N2O
Exact Mass: 310.106
Molecular Weight: 310.7452
Elemental Analysis: C, 50.25; H, 5.84; Cl, 11.41; F, 18.34; N, 9.02; O, 5.15


Related CAS #: 56341-08-3 (free base)   54240-36-7 (HCl)    

Synonym: Mabuterol; PB 868Cl;

IUPAC/Chemical Name: 4-Amino-alpha-((tert-butylamino)methyl)-3-chloro-5-(trifluoromethyl)benzyl alcohol

InChi Key: JSJCTEKTBOKRST-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3

SMILES Code: FC(C1=C(N)C(Cl)=CC(C(O)CNC(C)(C)C)=C1)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Song X, Zhao C, Dai C, Ren Y, An N, Wen H, Pan LI, Cheng M, Zhang Y. Suppression of the increasing level of acetylcholine-stimulated intracellular Ca(2+) in guinea pig airway smooth muscle cells by mabuterol. Biomed Rep. 2015 Nov;3(6):778-786. Epub 2015 Aug 4. PubMed PMID: 26623015; PubMed Central PMCID: PMC4660599.

2: Lu X, Liu P, Chen H, Qin F, Li F. Enantioselective pharmacokinetics of mabuterol in rats studied using sequential achiral and chiral HPLC. Biomed Chromatogr. 2005 Nov;19(9):703-8. PubMed PMID: 16206140.

3: Amemiya K, Asano T, Arika T, Nakamura M, Kudoh M. Special toxicology--physical dependence potential, antigenicity and mutagenicity--of mabuterol. Arzneimittelforschung. 1984;34(11A):1685-6. PubMed PMID: 6152162.

4: Tu Y, Zhong J, Wang H, Pan J, Xu Z, Yang W, Luo Y. Synthesis of stable isotope labeled D(9) -Mabuterol, D(9) -Bambuterol, and D(9) -Cimbuterol. J Labelled Comp Radiopharm. 2016 Nov;59(13):546-551. doi: 10.1002/jlcr.3446. Epub 2016 Oct 13. PubMed PMID: 27739098.

5: Osada E, Sakaya S, Sanai K, Seri K. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. III: Effects on the central nervous system, striated muscle and carbohydrate and lipid metabolism. Arzneimittelforschung. 1984;34(11A):1652-8. PubMed PMID: 6152158.

6: Yamamoto I, Matsuura E, Horiba M, Akima K, Nomura K, Aizawa T. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. PubMed PMID: 3900139.

7: Miyata T, Kai H, Furusawa K, Nakamura H, Saito M, Okano Y, Takahama K. Secretomotor and mucolytic effects of mabuterol, a novel bronchodilator. Arch Int Pharmacodyn Ther. 1987 Jul;288(1):147-60. PubMed PMID: 2889431.

8: Murai T, Maejima T, Sanai K, Osada E. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. I: Bronchodilating effect. Arzneimittelforschung. 1984;34(11A):1633-40. PubMed PMID: 6152156.

9: Guentert TW, Buskin JN, Galeazzi RL. Single dose pharmacokinetics of mabuterol in man. Arzneimittelforschung. 1984;34(11A):1691-6. PubMed PMID: 6152164.

10: Horiba M, Murai T, Nomura K, Yuge T, Sanai K, Osada E. Pharmacokinetic studies of mabuterol, a new selective beta 2-stimulant. II: Urinary metabolites of mabuterol in rats and their pharmacological effects. Arzneimittelforschung. 1984;34(11A):1668-79. PubMed PMID: 6152160.

11: Kawakami Y. First clinical studies on mabuterol. A summarizing report. Arzneimittelforschung. 1984;34(11A):1699-700. PubMed PMID: 6152166.

12: Amemiya K, Kudoh M, Suzuki H, Saga K, Hosaka K. Toxicology of mabuterol. Arzneimittelforschung. 1984;34(11A):1680-4. PubMed PMID: 6152161.

13: Ishizaki O, Daidohji S, Kimura K, Shibuya K, Horiguchi T, Sekiwa M. Reproduction studies with mabuterol in rats. Arzneimittelforschung. 1984;34(11A):1687-90. PubMed PMID: 6152163.

14: Osada E, Murai T, Ishizaka Y, Sanai K. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs. Arzneimittelforschung. 1984;34(11A):1641-51. PubMed PMID: 6152157.

15: Qureshi GA, Eriksson A. Determination of clenbuterol and mabuterol in equine plasma by ion-pair liquid chromatography with electrochemical detection. Chromatographic and electrochemical characteristics. J Chromatogr. 1988 May 27;441(1):197-205. PubMed PMID: 2900250.

16: Akahane K, Furukawa Y, Ogiwara Y, Haniuda M, Chiba S. Beta-adrenoceptor blocking effects of a selective beta 2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog. Br J Pharmacol. 1989 Jul;97(3):709-16. PubMed PMID: 2474351; PubMed Central PMCID: PMC1854580.

17: Nakamura M, Yamaya M, Fukushima T, Sekizawa K, Sasaki H, Takishima T. Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. Respiration. 1991;58(1):33-6. PubMed PMID: 1677208.

18: Yuge T, Hase T, Takayanagi Y, Kamasuka T, Amemiya K, Horiba M. Pharmacokinetic studies of mabuterol, a new selective beta 2-stimulant. I: Studies on the absorption, distribution and excretion in rats. Arzneimittelforschung. 1984;34(11A):1659-67. PubMed PMID: 6152159.

19: Ulmer WT, Scholz HJ, Baines A. Pilot clinical trial with a new beta 2-sympathomimetic bronchodilator, mabuterol. Arzneimittelforschung. 1984;34(11A):1697-8. PubMed PMID: 6152165.

20: Kim J, Shigetomi S, Tanaka K, Yamada ZO, Hashimoto S, Fukuchi S. [The role of beta 2-adrenoceptor on the pathogenesis of insulin resistance in essential hypertension]. Nihon Naibunpi Gakkai Zasshi. 1994 Jun 20;70(5):521-8. Japanese. PubMed PMID: 7958101.