NAAD sodium salt
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MedKoo CAT#: 561492

CAS#: 104809-30-5 (sodium)

Description: NAAD sodium salt initiates intracellular Ca2+ release by a cyclic ADP ribose-independent and IP3 mechanism. It is also used as a substrate to study the specificity and kinetics of nicotinamide adenine dinucleotide synthetase(s) (NADS).

Chemical Structure

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NAAD sodium salt
CAS# 104809-30-5 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 561492
Name: NAAD sodium salt
CAS#: 104809-30-5 (sodium)
Chemical Formula: C21H25N6NaO15P2
Exact Mass: 0.00
Molecular Weight: 686.390
Elemental Analysis: C, 36.75; H, 3.67; N, 12.24; Na, 3.35; O, 34.96; P, 9.03

Price and Availability

Size Price Availability Quantity
25mg USD 385 2 Weeks
100mg USD 885 2 Weeks
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Related CAS #: 6450-77-7 (free)   104809-30-5 (sodium)    

Synonym: NAAD sodium salt; NAAD Na salt; NAAD Na, NaAD; Deamido Nad Sodium Salt; Nicotinic acid adenine dinucleotide sodium salt;

IUPAC/Chemical Name: Sodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

InChi Key: LFHLUTZTSGEADU-RHANTIMGSA-M

InChi Code: InChI=1S/C21H26N6O15P2.Na/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,19-,20-;/m1./s1

SMILES Code: O=P(OP([O-])(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)=O)([O-])OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@H](O)[C@@H]4O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 686.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29. PubMed PMID: 15793621.

2: Patel S, Churchill GC, Galione A. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Biochem J. 2000 Dec 15;352 Pt 3:725-9. PubMed PMID: 11104679; PubMed Central PMCID: PMC1221510.