NAAD sodium salt
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MedKoo CAT#: 561492

CAS#: 104809-30-5

Description: NAAD sodium salt initiates intracellular Ca2+ release by a cyclic ADP ribose-independent and IP3 mechanism. It is also used as a substrate to study the specificity and kinetics of nicotinamide adenine dinucleotide synthetase(s) (NADS).


Price and Availability

Size
Price

25mg
USD 255
Size
Price

100mg
USD 580
Size
Price

NAAD sodium salt is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561492
Name: NAAD sodium salt
CAS#: 104809-30-5
Chemical Formula: C21H25N6NaO15P2
Exact Mass:
Molecular Weight: 686.39
Elemental Analysis: C, 36.75; H, 3.67; N, 12.24; Na, 3.35; O, 34.96; P, 9.03


Synonym: NAAD sodium salt; NAAD Na salt; NAAD Na, NaAD; Deamido Nad Sodium Salt; Nicotinic acid adenine dinucleotide sodium salt;

IUPAC/Chemical Name: Sodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

InChi Key: LFHLUTZTSGEADU-RHANTIMGSA-M

InChi Code: InChI=1S/C21H26N6O15P2.Na/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,19-,20-;/m1./s1

SMILES Code: O=P(OP([O-])(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)=O)([O-])OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@H](O)[C@@H]4O.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29. PubMed PMID: 15793621.

2: Patel S, Churchill GC, Galione A. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Biochem J. 2000 Dec 15;352 Pt 3:725-9. PubMed PMID: 11104679; PubMed Central PMCID: PMC1221510.