Maritinone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561490

CAS#: 33927-59-2

Description: Maritinone is a novel anti-tuberculosis (anti-TB) agent. It possess an interesting potential for development as a new drug against Mycobacterium tuberculosis, mainly resistant profile strains.


Price and Availability

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Maritinone is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561490
Name: Maritinone
CAS#: 33927-59-2
Chemical Formula: C22H14O6
Exact Mass: 374.079
Molecular Weight: 374.34
Elemental Analysis: C, 70.59; H, 3.77; O, 25.64


Synonym: Maritinone;

IUPAC/Chemical Name: 5-Hydroxy-8-(4-hydroxy-7-methyl-5,8-dioxonaphthalen-1-yl)-2-methylnaphthalene-1,4-dione

InChi Key: XCRMWTKECYDCOD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H14O6/c1-9-7-15(25)19-13(23)5-3-11(17(19)21(9)27)12-4-6-14(24)20-16(26)8-10(2)22(28)18(12)20/h3-8,23-24H,1-2H3

SMILES Code: O=C1C(C)=CC(C2=C1C(C(C=CC(O)=C3C(C=C4C)=O)=C3C4=O)=CC=C2O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ito C, Matsui T, Takano M, Wu TS, Itoigawa M. Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica. Nat Prod Res. 2017 Aug 20:1-6. doi: 10.1080/14786419.2017.1366476. [Epub ahead of print] PubMed PMID: 28823173.

2: Higa M, Takashima Y, Yokaryo H, Harie Y, Suzuka T, Ogihara K. Naphthoquinone Derivatives from Diospyros maritima. Chem Pharm Bull (Tokyo). 2017;65(8):739-745. doi: 10.1248/cpb.c17-00178. PubMed PMID: 28768928.

3: Sharma D, Yadav JP. An Overview of Phytotherapeutic Approaches for the Treatment of Tuberculosis. Mini Rev Med Chem. 2017;17(2):167-183. Review. PubMed PMID: 27145855.

4: Uc-Cachón AH, Borges-Argáez R, Said-Fernández S, Vargas-Villarreal J, González-Salazar F, Méndez-González M, Cáceres-Farfán M, Molina-Salinas GM. Naphthoquinones isolated from Diospyros anisandra exhibit potent activity against pan-resistant first-line drugs Mycobacterium tuberculosis strains. Pulm Pharmacol Ther. 2014 Feb;27(1):114-20. doi: 10.1016/j.pupt.2013.08.001. Epub 2013 Aug 20. PubMed PMID: 23968826.

5: Quintal-Novelo C, Moo-Puc RE, Chale-Dzul J, Cáceres-Farfán M, Mendez-Gonzalez M, Borges-Argáez R. Cytotoxic constituents from the stem bark of Diospyros cuneata Standl. Nat Prod Res. 2013;27(17):1594-7. doi: 10.1080/14786419.2012.738201. Epub 2012 Oct 26. PubMed PMID: 23098219.

6: Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC. Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima. J Nat Prod. 2012 Mar 23;75(3):394-9. doi: 10.1021/np200805z. Epub 2012 Feb 7. PubMed PMID: 22313254; PubMed Central PMCID: PMC3311710.

7: Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO 3rd, Wall ME, Wani MC, Kinghorn AD, Oberlies NH. Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod. 2004 Jul;67(7):1156-61. PubMed PMID: 15270571.

8: Lin LC, Yang LL, Chou CJ. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica. Phytochemistry. 2003 Feb;62(4):619-22. PubMed PMID: 12560036.