Oe-9000
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561471

CAS#: 675132-92-0

Description: Oe-9000 is a novel blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces slowly activating and inactivating tetrodotoxin-resistant (TTX-R) Na(+) currents as well as rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents at low micromolar concentrations.


Price and Availability

Size
Price

5g
USD 6350
Size
Price

25g
USD 22550
Size
Price

Oe-9000 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561471
Name: Oe-9000
CAS#: 675132-92-0
Chemical Formula: C21H29NO3
Exact Mass: 343.2147
Molecular Weight: 343.47
Elemental Analysis: C, 73.44; H, 8.51; N, 4.08; O, 13.97


Synonym: Oe-9000; Oe 9000; Oe9000;

IUPAC/Chemical Name: 2,2'-((4-(4-(phenoxymethyl)phenyl)butyl)azanediyl)bis(ethan-1-ol)

InChi Key: WRYVVYWBQAWWQN-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H29NO3/c23-16-14-22(15-17-24)13-5-4-6-19-9-11-20(12-10-19)18-25-21-7-2-1-3-8-21/h1-3,7-12,23-24H,4-6,13-18H2

SMILES Code: OCCN(CCO)CCCCC1=CC=C(COC2=CC=CC=C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Baumgart M, Feller C, Natura G, Dahse T, Schaible HG, Dahse I. Blockade of TTX-resistant and TTX-sensitive Na+ currents in cultured dorsal root ganglion neurons by fomocaine and the fomocaine derivative Oe 9000. Brain Res. 2010 Oct 28;1358:54-63. doi: 10.1016/j.brainres.2010.08.033. Epub 2010 Aug 19. PubMed PMID: 20727863.

2: Dahse T, Wennek-Klose J, Listing M, Fleck C, Oelschläger H. [In vitro investigations of phase I metabolism of the fomocaine derivative Oe 9000 with pig liver homogenates]. Pharmazie. 2006 Nov;61(11):943-51. German. PubMed PMID: 17152988.

3: Fleck C, Wennek-Klose J, Wange J, Oelschläger H. Effects and toxicity of new fomocaine derivatives and of 2-hydroxypropyl-beta-cyclodextrin inclusion compounds in rats. Arzneimittelforschung. 2004;54(5):265-74. PubMed PMID: 15212188.

4: Fleck C, Karge E, Loy S, Wennek-Klose J, Listing M, Oelschläger H. Local anaesthetic effects and toxicity of seven new diethanolamine and morpholine derivatives of fomocaine. Testing in rats compared with procaine and tetracaine. Arzneimittelforschung. 2003;53(3):221-8. PubMed PMID: 12705179.