BIBS-222

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561456

CAS#: 142023-57-2

Description: BIBS-222 is a novel nonpeptide angiotensin II (Ang II) receptor antagonist. BIBS 222 appears to be an effective antihypertensive in the model of the renal hypertensive rat.


Chemical Structure

img
BIBS-222
CAS# 142023-57-2

Theoretical Analysis

MedKoo Cat#: 561456
Name: BIBS-222
CAS#: 142023-57-2
Chemical Formula: C33H37Cl2N5O4
Exact Mass: 637.22
Molecular Weight: 638.600
Elemental Analysis: C, 62.07; H, 5.84; Cl, 11.10; N, 10.97; O, 10.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BIBS-222; BIBS 222; BIBS222;

IUPAC/Chemical Name: 2-((4-((2-butyl-6-(3-methyl-1-pentylureido)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)carbamoyl)-3,6-dichlorobenzoic acid

InChi Key: ZHWGRXBJGUEATA-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H37Cl2N5O4/c1-4-6-8-18-39(33(44)36-3)23-14-17-26-27(19-23)40(28(38-26)9-7-5-2)20-21-10-12-22(13-11-21)37-31(41)29-24(34)15-16-25(35)30(29)32(42)43/h10-17,19H,4-9,18,20H2,1-3H3,(H,36,44)(H,37,41)(H,42,43)

SMILES Code: CCCCCN(C(NC)=O)C1=CC(N(CC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3C(O)=O)=O)C=C2)C(CCCC)=N4)=C4C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 638.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhang J, Pfaffendorf M, van Zwieten PA. Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. J Cardiovasc Pharmacol. 1995 May;25(5):724-31. PubMed PMID: 7630151.

2: Zhang J, Pfaffendorf M, van Zwieten PA. Effect of various angiotensin receptor antagonists on cardiovascular responses to angiotensin II in pithed rats. J Cardiovasc Pharmacol. 1994 Jul;24(1):108-13. PubMed PMID: 7521474.

3: Zhang JS, Van Meel JC, Pfaffendorf M, Van Zwieten PA. Different types of angiotensin II receptor antagonism induced by BIBS 222 in the rat portal vein and rabbit aorta; the influence of receptor reserve. J Pharmacol Exp Ther. 1994 May;269(2):509-14. PubMed PMID: 8182519.

4: Zhang JS, van Meel JC, Pfaffendorf M, van Zwieten PA. Inhibitory effect of dithiothreitol on angiotensin II-induced contractions mediated by AT1-receptors in rat portal vein and rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):538-42. PubMed PMID: 8065468.

5: Zhang J, Van Meel JC, Van Zwieten PA. Antihypertensive activity of the novel, nonpeptide angiotensin II receptor antagonists BIBS 39 and BIBS 222 in conscious renal hypertensive rats. Pharmacology. 1993 May;46(5):241-7. PubMed PMID: 8488169.

6: van Meel JC, Entzeroth M, Hauel N, Narr B, Ries U, Wienen W. Angiotensin II receptor antagonists. Arzneimittelforschung. 1993 Feb;43(2A):242-6. Review. PubMed PMID: 8498971.

7: Zhang J, Entzeroth M, Wienen W, Van Meel JC. Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin II receptor antagonists. Eur J Pharmacol. 1992 Jul 21;218(1):35-41. PubMed PMID: 1397034.