Cimaterol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571315

CAS#: 54239-37-1

Description: Cimaterol is a beta-adrenoceptor agonist that work with beta-adrenoceptors and leads to increased weight gain in the skeletal muscle. It has been shown to stimulate lipolysis.

Chemical Structure

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Cimaterol
CAS# 54239-37-1
Instruction

Theoretical Analysis

MedKoo Cat#: 571315
Name: Cimaterol
CAS#: 54239-37-1
Chemical Formula: C12H17N3O
Exact Mass: 219.14
Molecular Weight: 219.290
Elemental Analysis: C, 65.73; H, 7.81; N, 19.16; O, 7.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Cimaterol

IUPAC/Chemical Name: Benzonitrile, 2-amino-5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (+-)-

InChi Key: BUXRLJCGHZZYNE-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H17N3O/c1-8(2)15-7-12(16)9-3-4-11(14)10(5-9)6-13/h3-5,8,12,15-16H,7,14H2,1-2H3

SMILES Code: N#CC1=CC(C(O)CNC(C)C)=CC=C1N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 219.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kim YS, Sainz RD, Summers RJ, Molenaar P. Cimaterol reduces beta-adrenergic receptor density in rat skeletal muscles. J Anim Sci. 1992 Jan;70(1):115-22. PubMed PMID: 1374751.

2: Eadara JK, Dalrymple RH, DeLay RL, Ricks CA, Romsos DR. Effects of cimaterol, a beta-adrenergic agonist, on lipid metabolism in rats. Metabolism. 1989 Jun;38(6):522-9. PubMed PMID: 2566888.

3: Eisen EJ, Croom WJ Jr, Helton SW. Differential response to the beta-adrenergic agonist cimaterol in mice selected for rapid gain and unselected controls. J Anim Sci. 1988 Feb;66(2):361-71. PubMed PMID: 2897353.

4: Chikhou FH, Moloney AP, Allen P, Quirke JF, Austin FH, Roche JF. Long-term effects of cimaterol in Friesian steers: I. Growth, feed efficiency, and selected carcass traits. J Anim Sci. 1993 Apr;71(4):906-13. PubMed PMID: 8097508.

5: Walker WR, Johnson DD, Brendemuhl JH, Dalrymple RH, Combs GE. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J Anim Sci. 1989 Jan;67(1):168-76. PubMed PMID: 2564387.

6: Walker HC, Romsos DR. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255(6 Pt 2):R952-60. PubMed PMID: 2904775.

7: Jones RW, Easter RA, McKeith FK, Dalrymple RH, Maddock HM, Bechtel PJ. Effect of the beta-adrenergic agonist cimaterol (CL 263,780) on the growth and carcass characteristics of finishing swine. J Anim Sci. 1985 Oct;61(4):905-13. PubMed PMID: 2866174.

8: Stallion A, Foley-Nelson T, Chance WT, James JH, Fischer JE. Anticatabolic effect of the beta 2-agonist cimaterol in vivo in tumor-bearing animals. J Surg Res. 1995 Sep;59(3):387-92. PubMed PMID: 7643598.

9: Forsberg NE, Wehr NB. Effects of cimaterol on muscle protein metabolism and its actions in hypothyroid and hyperthyroid rats. Domest Anim Endocrinol. 1990 Apr;7(2):149-63. PubMed PMID: 1695129.

10: Stallion A, Zhang FS, Chance WT, Foley-Nelson T, Fischer JE. Reversal of cancer cachexia in rats by cimaterol and supplemental nutrition. Surgery. 1991 Oct;110(4):678-84. PubMed PMID: 1681593.

11: Chikhou FH, Moloney AP, Allen P, Joseph RL, Tarrant PV, Quirke JF, Austin FH, Roche JF. Long-term effects of cimaterol in Friesian steers: II. Carcass composition and meat quality. J Anim Sci. 1993 Apr;71(4):914-22. PubMed PMID: 8097509.

12: Rikhardsson G, Johnson KA, Johnson DE. Effects of cimaterol on energetics and carcass characteristics of Suffolk ewe lambs. J Anim Sci. 1991 Jan;69(1):396-404. PubMed PMID: 1672310.

13: Akanbi KA, Hu CY. Effect of dietary cimaterol on Na(+)-K+ ATPase activity in rabbit tissues. J Anim Sci. 1991 Sep;69(9):3597-602. PubMed PMID: 1657851.

14: Eadara JK, Dalrymple RH, DeLay RL, Ricks CA, Romsos DR. Effects of cimaterol, a beta-adrenergic agonist, on protein metabolism in rats. Metabolism. 1989 Sep;38(9):883-90. PubMed PMID: 2475743.

15: Wang SY, Beermann DH. Reduced calcium-dependent proteinase activity in cimaterol-induced muscle hypertrophy in lambs. J Anim Sci. 1988 Oct;66(10):2545-50. PubMed PMID: 2848794.

16: Sainz RD, Wolff JE. Effects of the beta-agonist, cimaterol, on growth, body composition and energy expenditure in rats. Br J Nutr. 1988 Jul;60(1):85-90. PubMed PMID: 2900650.

17: Duan J, Chen H, Chen Y, Huang Y, Chen G. [Simultaneous determination of cimaterol, clenbuterol and salbutamol in feeds by capillary zone electrophoresis]. Se Pu. 2005 May;23(3):261-3. Chinese. PubMed PMID: 16124569.

18: Nash JE, Rocha HJ, Buchan V, Calder GA, Milne E, Quirke JF, Lobley GE. The effect of acute and chronic administration of the beta-agonist, cimaterol, on protein synthesis in ovine skin and muscle. Br J Nutr. 1994 Apr;71(4):501-13. PubMed PMID: 7912105.

19: Beermann DH, Butler WR, Hogue DE, Fishell VK, Dalrymple RH, Ricks CA, Scanes CG. Cimaterol-induced muscle hypertrophy and altered endocrine status in lambs. J Anim Sci. 1987 Dec;65(6):1514-24. Erratum in: J Anim Sci 1988 May;66(5):1320. PubMed PMID: 2895097.

20: Forsberg NE, Ilian MA, Ali-Bar A, Cheeke PR, Wehr NB. Effects of cimaterol on rabbit growth and myofibrillar protein degradation and on calcium-dependent proteinase and calpastatin activities in skeletal muscle. J Anim Sci. 1989 Dec;67(12):3313-21. PubMed PMID: 2482286. ^