gamma-Tocotrienol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561439

CAS#: 14101-61-2

Description: gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. gamma-Tocotrienol is a radioprotector, antioxidant, and shows antitumor and antihypertensive effects in vivo.


Price and Availability

Size
Price

5mg
USD 245
Size
Price

10mg
USD 420
Size
Price

25mg
USD 820

gamma-Tocotrienol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561439
Name: gamma-Tocotrienol
CAS#: 14101-61-2
Chemical Formula: C28H42O2
Exact Mass: 410.3185
Molecular Weight: 410.64
Elemental Analysis: C, 81.90; H, 10.31; O, 7.79


Synonym: Plastochromanol; D-gamma-Tocotrienol; gamma-Tocotrienol; gamma Tocotrienol; gammaTocotrienol;

IUPAC/Chemical Name: (2R)-2,7,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol

InChi Key: OTXNTMVVOOBZCV-WAZJVIJMSA-N

InChi Code: InChI=1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1

SMILES Code: OC1=CC(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C2C(C)=C1C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hofer M, Hoferová Z, Falk M. Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines? Int J Mol Sci. 2017 Jun 28;18(7). pii: E1385. doi: 10.3390/ijms18071385. Review. PubMed PMID: 28657605; PubMed Central PMCID: PMC5535878.

2: Singh VK, Hauer-Jensen M. γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. Int J Mol Sci. 2016 May 3;17(5). pii: E663. doi: 10.3390/ijms17050663. Review. PubMed PMID: 27153057; PubMed Central PMCID: PMC4881489.

3: Zhao L, Fang X, Marshall MR, Chung S. Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols. Molecules. 2016 Mar 11;21(3):344. doi: 10.3390/molecules21030344. Review. PubMed PMID: 26978344.

4: Davis-Yadley AH, Malafa MP. Vitamins in pancreatic cancer: a review of underlying mechanisms and future applications. Adv Nutr. 2015 Nov 13;6(6):774-802. doi: 10.3945/an.115.009456. Print 2015 Nov. Review. PubMed PMID: 26567201; PubMed Central PMCID: PMC4642423.

5: Ahsan H, Ahad A, Iqbal J, Siddiqui WA. Pharmacological potential of tocotrienols: a review. Nutr Metab (Lond). 2014 Nov 12;11(1):52. doi: 10.1186/1743-7075-11-52. eCollection 2014. Review. PubMed PMID: 25435896; PubMed Central PMCID: PMC4247006.

6: Kruk J, Szymańska R, Cela J, Munne-Bosch S. Plastochromanol-8: fifty years of research. Phytochemistry. 2014 Dec;108:9-16. doi: 10.1016/j.phytochem.2014.09.011. Epub 2014 Oct 9. Review. PubMed PMID: 25308762.

7: Jiang Q. Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radic Biol Med. 2014 Jul;72:76-90. doi: 10.1016/j.freeradbiomed.2014.03.035. Epub 2014 Apr 3. Review. PubMed PMID: 24704972; PubMed Central PMCID: PMC4120831.

8: Singh VK, Beattie LA, Seed TM. Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures. J Radiat Res. 2013 Nov 1;54(6):973-88. doi: 10.1093/jrr/rrt048. Epub 2013 May 8. Review. PubMed PMID: 23658414; PubMed Central PMCID: PMC3823775.

9: Sylvester PW, Ayoub NM. Tocotrienols target PI3K/Akt signaling in anti-breast cancer therapy. Anticancer Agents Med Chem. 2013 Sep;13(7):1039-47. Review. PubMed PMID: 23272909.

10: Berbée M, Hauer-Jensen M. Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? Curr Opin Support Palliat Care. 2012 Mar;6(1):54-9. doi: 10.1097/SPC.0b013e32834e3bd7. Review. PubMed PMID: 22228028; PubMed Central PMCID: PMC3677768.

11: Sylvester PW, Wali VB, Bachawal SV, Shirode AB, Ayoub NM, Akl MR. Tocotrienol combination therapy results in synergistic anticancer response. Front Biosci (Landmark Ed). 2011 Jun 1;16:3183-95. Review. PubMed PMID: 21622228.

12: Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010 Sep;29(3):405-34. doi: 10.1007/s10555-010-9235-2. Review. PubMed PMID: 20737283; PubMed Central PMCID: PMC2996866.

13: Kulkarni S, Ghosh SP, Hauer-Jensen M, Kumar KS. Hematological targets of radiation damage. Curr Drug Targets. 2010 Nov;11(11):1375-85. Review. PubMed PMID: 20583980.

14: Haussler MR, Haussler CA, Bartik L, Whitfield GK, Hsieh JC, Slater S, Jurutka PW. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr Rev. 2008 Oct;66(10 Suppl 2):S98-112. doi: 10.1111/j.1753-4887.2008.00093.x. Review. PubMed PMID: 18844852.

15: Szymańska R, Kruk J. [Occurrence and function of tocochromanols in plants, animals and men]. Postepy Biochem. 2007;53(2):174-81. Review. Polish. PubMed PMID: 17969879.

16: Rapaka RS, Coates PM. Dietary supplements and related products: a brief summary. Life Sci. 2006 Mar 27;78(18):2026-32. Epub 2006 Feb 23. Review. PubMed PMID: 16497339.

17: Brigelius-Flohé R. Induction of drug metabolizing enzymes by vitamin E. J Plant Physiol. 2005 Jul;162(7):797-802. Review. PubMed PMID: 16008107.

18: Mo H, Elson CE. Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Exp Biol Med (Maywood). 2004 Jul;229(7):567-85. Review. PubMed PMID: 15229351.

19: Elson CE, Yu SG. The chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables. J Nutr. 1994 May;124(5):607-14. Review. PubMed PMID: 8169651.