NSC-668394

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561437

CAS#: 382605-72-3

Description: NSC-668394 is a small molecule ezrin inhibitor. NSC-668394 inhibits ezrin phosphorylation, ezrin-actin interaction and ezrin-mediated motility of osteosarcoma (OS) cells in culture. NSC-668394 demonstrates a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis.

Chemical Structure

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NSC-668394
CAS# 382605-72-3
Instruction

Theoretical Analysis

MedKoo Cat#: 561437
Name: NSC-668394
CAS#: 382605-72-3
Chemical Formula: C17H12Br2N2O3
Exact Mass: 449.92
Molecular Weight: 452.100
Elemental Analysis: C, 45.16; H, 2.68; Br, 35.35; N, 6.20; O, 10.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NSC-668394; NSC 668394; NSC668394;

IUPAC/Chemical Name: 7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione

InChi Key: OHPHDPYJEHZGDE-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12Br2N2O3/c18-11-6-9(7-12(19)16(11)23)3-5-20-13-8-14(22)10-2-1-4-21-15(10)17(13)24/h1-2,4,6-8,20,23H,3,5H2

SMILES Code: O=C(C=C1NCCC2=CC(Br)=C(O)C(Br)=C2)C3=C(N=CC=C3)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 452.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Andharia N, Joseph A, Hayashi M, Okada M, Matsuda H. Involvement of intracellular transport in TREK-1c current run-up in 293T cells. Channels (Austin). 2017 May 4;11(3):224-235. doi: 10.1080/19336950.2017.1279368. Epub 2017 Jan 13. PubMed PMID: 28085542; PubMed Central PMCID: PMC5463894.

2: Çelik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, Özdemirli M, Ayhan A, Rudek MA, Toretsky JA, Üren A. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70. doi: 10.1074/jbc.M116.718189. Epub 2016 May 2. PubMed PMID: 27137931; PubMed Central PMCID: PMC4933238.

3: Pore D, Bodo J, Danda A, Yan D, Phillips JG, Lindner D, Hill BT, Smith MR, Hsi ED, Gupta N. Identification of Ezrin-Radixin-Moesin proteins as novel regulators of pathogenic B-cell receptor signaling and tumor growth in diffuse large B-cell lymphoma. Leukemia. 2015 Sep;29(9):1857-67. doi: 10.1038/leu.2015.86. Epub 2015 Mar 24. PubMed PMID: 25801911; PubMed Central PMCID: PMC4558318.

4: Ren L, Khanna C. Role of ezrin in osteosarcoma metastasis. Adv Exp Med Biol. 2014;804:181-201. doi: 10.1007/978-3-319-04843-7_10. Review. PubMed PMID: 24924175.

5: Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I, Toretsky JA, Khanna C, Uren A. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. doi: 10.1038/onc.2011.245. Epub 2011 Jun 27. PubMed PMID: 21706056; PubMed Central PMCID: PMC3513970.