S-40503

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530915

CAS#: 404920-28-1

Description: S-40503 is an investigational selective androgen receptor modulator (SARM) developed by the Japanese company Kaken Pharmaceuticals, which was developed for the treatment of osteoporosis. SARMs are a new class of drugs which produce tissue-specific anabolic effects in some tissues such as muscle and bone, but without stimulating androgen receptors in other tissues such as in the prostate gland, thus avoiding side effects such as benign prostatic hypertrophy which can occur following treatment with unselective androgens like testosterone or anabolic steroids.


Price and Availability

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S-40503 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530915
Name: S-40503
CAS#: 404920-28-1
Chemical Formula: C15H23N3O3
Exact Mass: 293.1739
Molecular Weight: 293.367
Elemental Analysis: C, 61.41; H, 7.90; N, 14.32; O, 16.36


Synonym: S-40503; S40503; S40503.

IUPAC/Chemical Name: 2-[4-(Dimethylamino)-6-nitro-1,2,3,4-tetrahydro-2-chinolinyl]-2-methyl-1-propanol

InChi Key: YNYAUBNZRZVNLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H23N3O3/c1-15(2,9-19)14-8-13(17(3)4)11-7-10(18(20)21)5-6-12(11)16-14/h5-7,13-14,16,19H,8-9H2,1-4H3

SMILES Code: CC(C)(C1NC2=C(C=C([N+]([O-])=O)C=C2)C(N(C)C)C1)CO


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Thevis M, Schänzer W. Detection of SARMs in doping control analysis. Mol Cell
Endocrinol. 2017 Jan 27. pii: S0303-7207(17)30053-9. doi:
10.1016/j.mce.2017.01.040. [Epub ahead of print] PubMed PMID: 28137616.

2: Kearbey JD, Gao W, Fisher SJ, Wu D, Miller DD, Dalton JT. Effects of selective
androgen receptor modulator (SARM) treatment in osteopenic female rats. Pharm
Res. 2009 Nov;26(11):2471-7. doi: 10.1007/s11095-009-9962-7. Epub 2009 Sep 1.
PubMed PMID: 19728047.

3: Thevis M, Beuck S, Thomas A, Kortner B, Kohler M, Rodchenkov G, Schänzer W.
Doping control analysis of emerging drugs in human plasma - identification of
GW501516, S-107, JTV-519, and S-40503. Rapid Commun Mass Spectrom. 2009
Apr;23(8):1139-46. doi: 10.1002/rcm.3987. PubMed PMID: 19280612.

4: Hanada K, Furuya K, Yamamoto N, Nejishima H, Ichikawa K, Nakamura T, Miyakawa
M, Amano S, Sumita Y, Oguro N. Bone anabolic effects of S-40503, a novel
nonsteroidal selective androgen receptor modulator (SARM), in rat models of
osteoporosis. Biol Pharm Bull. 2003 Nov;26(11):1563-9. PubMed PMID: 14600402.