S6K1-IN-DG2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561433

CAS#: 871340-88-4

Description: S6K1-IN-DG2 is a potent and selective inhibitor of p70 ribosomal S6 kinase 1 (S6K1). S6K1-IN-DG2 is also ATP-competitive and cell-permeable.


Price and Availability

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S6K1-IN-DG2 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561433
Name: S6K1-IN-DG2
CAS#: 871340-88-4
Chemical Formula: C16H17BrN6O
Exact Mass: 388.0647
Molecular Weight: 389.26
Elemental Analysis: C, 49.37; H, 4.40; Br, 20.53; N, 21.59; O, 4.11


Synonym: S6K1 Inhibitor DG2; S6K1-Inhibitor-DG2; S6K1InhibitorDG2; S6K1-IN-DG2; S6K1 IN DG2; S6K1INDG2;

IUPAC/Chemical Name: 3-Bromo-4-[4-(2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

InChi Key: CQXAPCMYRSTDGK-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17BrN6O/c1-24-12-5-3-2-4-11(12)22-6-8-23(9-7-22)16-13-14(17)20-21-15(13)18-10-19-16/h2-5,10H,6-9H2,1H3,(H,18,19,20,21)

SMILES Code: COC1=CC=CC=C1N2CCN(C3=C4C(NN=C4Br)=NC=N3)CC2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM. Inhibitor hijacking of Akt activation. Nat Chem Biol. 2009 Jul;5(7):484-93. doi: 10.1038/nchembio.183. Epub 2009 May 24. PubMed PMID: 19465931; PubMed Central PMCID: PMC2783590.