BFF122

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561429

CAS#: 1152314-49-2

Description: BFF122 is a kynurenine aminotransferase II (KAT II) inhibitor. KAT II catalyzes transamination of L-kynurenine in astrocytes, a precursor to kynurenic acid (KYNA) that acts as a neuroactive metabolite.


Price and Availability

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BFF122 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561429
Name: BFF122
CAS#: 1152314-49-2
Chemical Formula: C17H19FN4O4
Exact Mass: 362.139
Molecular Weight: 362.36
Elemental Analysis: C, 56.35; H, 5.29; F, 5.24; N, 15.46; O, 17.66


Synonym: BFF122; BFF 122; BFF-122; BF5;

IUPAC/Chemical Name: (S)-9-(4-Amino-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid

InChi Key: ICQVSZFWVUBYSI-VIFPVBQESA-N

InChi Code: InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1

SMILES Code: O=C(C(C1=O)=CN2[C@@H](C)COC3=C2C1=CC(F)=C3N4CCN(N)CC4)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Alkondon M, Pereira EF, Eisenberg HM, Kajii Y, Schwarcz R, Albuquerque EX. Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain. J Pharmacol Exp Ther. 2011 Jun;337(3):572-82. doi: 10.1124/jpet.110.177386. Epub 2011 Jan 26. PubMed PMID: 21270133; PubMed Central PMCID: PMC3101010.

2: Rossi F, Valentina C, Garavaglia S, Sathyasaikumar KV, Schwarcz R, Kojima S, Okuwaki K, Ono S, Kajii Y, Rizzi M. Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem. 2010 Aug 12;53(15):5684-9. doi: 10.1021/jm100464k. PubMed PMID: 20684605; PubMed Central PMCID: PMC3929320.