Naphazoline HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540308

CAS#: 550-99-2

Description: Naphazoline HCl is an α1-Adrenergic receptor agonist used to treat congestion and ocular pathologies. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation.


Price and Availability

Size
Price

10g
USD 200
Size
Price

Size
Price

Naphazoline HCl purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 540308
Name: Naphazoline HCl
CAS#: 550-99-2
Chemical Formula: C14H15ClN2
Exact Mass: 246.0924
Molecular Weight: 246.73
Elemental Analysis: C, 68.15; H, 6.13; Cl, 14.37; N, 11.35


Synonym: Albalon Liquifilm; Nafazair; Naphazoline HCl; Rhinantin; Vasocon

IUPAC/Chemical Name: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride

InChi Key: DJDFFEBSKJCGHC-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

SMILES Code: [H]Cl.C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: van Montfrans GA, van Steenwijk RP, Vyth A, Borst C. Intravenous naphazoline intoxication. Acta Med Scand. 1981;209(5):429-30. PubMed PMID: 7246278.

2: Uncini A, De Nicola G, Di Muzio A, Rancitelli G, Colangelo L, Gambi D, Gallenga PE. Topical naphazoline in treatment of myopathic ptosis. Acta Neurol Scand. 1993 Apr;87(4):322-4. PubMed PMID: 8503264.

3: Dockhorn RJ, Duckett TG. Comparison of Naphcon-A and its components (naphazoline and pheniramine) in a provocative model of allergic conjunctivitis. Curr Eye Res. 1994 May;13(5):319-24. PubMed PMID: 8055694.

4: van de Donk HJ, Zuidema J, Merkus FW. Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs. Rhinology. 1982 Jun;20(2):81-7. PubMed PMID: 6180466.

5: Le Pelley E, Klossek JM, Bouquet S, Ferrier B, Fusciardi J. [Cocaine contact anesthesia for endonasal surgery. Kinetics and clinical tolerance of a concentrated solution]. Ann Fr Anesth Reanim. 1995;14(6):472-7. French. PubMed PMID: 8745970.

6: Hiramoto T, Kushida H, Endoh M. Further characterization of the myocardial alpha-adrenoceptors mediating positive inotropic effects in the rabbit myocardium. Eur J Pharmacol. 1988 Aug 2;152(3):301-10. PubMed PMID: 2906004.