Ro 10-5824 | CAS#189744-46-5

RO10-5824
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530904

CAS#: 189744-46-5

Description: RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders.

Chemical Structure

RO10-5824

CAS# 189744-46-5

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530904
Name: RO10-5824
CAS#: 189744-46-5
Chemical Formula: C17H20N4
Exact Mass: 280.17
Molecular Weight: 280.380
Elemental Analysis: C, 72.83; H, 7.19; N, 19.98

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 1350
200mg	USD 1850
500mg	USD 2650
1g	USD 3450
2g	USD 4850
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824.

IUPAC/Chemical Name: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine

InChi Key: KABDATZAOUSYES-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N4/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20)

SMILES Code: NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	RO10-5824 is a D4-selective partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM), and is approximately 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
In vitro activity:	To be determined
In vivo activity:	This study presents data from self administration studies in nonhuman primates that shows that intravenous cocaine-maintained behavior is moderately decreased by doses of Ro10-5824. Reference: CNS Neurol Disord Drug Targets. 2015;14(6):707-15. https://pubmed.ncbi.nlm.nih.gov/26022267/

Preparing Stock Solutions

The following data is based on the product molecular weight 280.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Bergman J, Rheingold CG. Dopamine D₄ Receptor Antagonists for the Treatment of Cocaine Use Disorders. CNS Neurol Disord Drug Targets. 2015;14(6):707-15. doi: 10.2174/1871527314666150529132723. PMID: 26022267. 2. Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M. Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone. Behav Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec 1. PMID: 24304719.
In vitro protocol:	To be determined
In vivo protocol:	1. Bergman J, Rheingold CG. Dopamine D₄ Receptor Antagonists for the Treatment of Cocaine Use Disorders. CNS Neurol Disord Drug Targets. 2015;14(6):707-15. doi: 10.2174/1871527314666150529132723. PMID: 26022267. 2. Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M. Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone. Behav Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec 1. PMID: 24304719.

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1: Bergman J, Rheingold CG. Dopamine D₄ Receptor Antagonists for the Treatment of
Cocaine Use Disorders. CNS Neurol Disord Drug Targets. 2015;14(6):707-15. Review.
PubMed PMID: 26022267.

2: Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M. Lack of dopamine
D4 receptor affinity contributes to the procognitive effect of lurasidone. Behav
Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec
1. PubMed PMID: 24304719.

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