GN44028
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MedKoo CAT#: 561395

CAS#: 1421448-26-1

Description: GN44028 inhibits HIF-1α. GN44028 suppresses HIF-1α transcriptional activity without affecting both HIF-1α protein accumulation and HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions, suggesting that GN44028 probably affectes the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer.

Chemical Structure

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GN44028
CAS# 1421448-26-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561395
Name: GN44028
CAS#: 1421448-26-1
Chemical Formula: C18H15N3O2
Exact Mass: 305.12
Molecular Weight: 305.337
Elemental Analysis: C, 70.81; H, 4.95; N, 13.76; O, 10.48

Price and Availability

Size Price Availability Quantity
10mg USD 450 2 Weeks
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Synonym: GN44028; GN 44028; GN-44028;

IUPAC/Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

InChi Key: CGZKSZVSWAAUHE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)

SMILES Code: C12=C(CC3=C2C=CC=C3)C(NC4=CC=C(OCCO5)C5=C4)=NN1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1α inhibitor, with an IC50 of 14 nM.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.3 131.87
Ethanol 30.5 99.99

Preparing Stock Solutions

The following data is based on the product molecular weight 305.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Hidemitsu Minegishi, Shinji Fukashiro, Hyun Seung Ban, and Hiroyuki Nakamura. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan. ACS Med. Chem. Lett., 2013, 4 (2), pp 297–301 DOI: 10.1021/ml3004632 Publication Date (Web): January 27, 2013.