A1777

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571278

CAS#: 90316-11-3

Description: A1777 is a selective 5-lipoxygenase inhibitor that reduces leukocytes proliferation without affecting the eosinophils of mast cells.


Price and Availability

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Price

Size
Price

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AA1777 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571278
Name: A1777
CAS#: 90316-11-3
Chemical Formula: C21H24O4
Exact Mass: 340.1675
Molecular Weight: 340.42
Elemental Analysis: C, 74.09; H, 7.11; O, 18.80


Synonym: AA1777; AA-1777; AA 1777

IUPAC/Chemical Name: 2,7-Dodecadiynoic acid, 12-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-

InChi Key: SOXDIYGAYKFKPK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H24O4/c1-15-16(2)21(25)18(17(3)20(15)24)13-11-9-7-5-4-6-8-10-12-14-19(22)23/h6-11,13H2,1-3H3,(H,22,23)

SMILES Code: O=C(O)C#CCCCC#CCCCCC1=C(C)C(C(C)=C(C)C1=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tanaka K, Ueno A, Katori M. Roles of leukotrienes in two rat allergic inflammatory models; IgE-mediated and IgG-antigen complex-induced pleurisies. Prostaglandins. 1986 Jun;31(6):1099-116. PubMed PMID: 3020615.

2: Qian J, Steigerwald K, Combs KA, Barton MC, Groden J. Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. Oncogene. 2007 Jul 19;26(33):4872-6. Epub 2007 Feb 5. PubMed PMID: 17297457.

3: Nagai K, Katori M. Possible changes in the leukocyte membrane as a mechanism of leukocyte adhesion to the venular walls induced by leukotriene B4 and fMLP in the microvasculature of the hamster cheek pouch. Int J Microcirc Clin Exp. 1988 Nov;7(4):305-14. PubMed PMID: 2851564.