VU0410150

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561387

CAS#: 1296731-74-2

Description: VU0410150 is a pyrrylarylsulfone containing compound and has been found to be a mGluR4-positive allosteric modulator. VU0410150 has been evaluated as a potential drug for the treatment for Parkinson’s disease.

Chemical Structure

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VU0410150
CAS# 1296731-74-2
Instruction

Theoretical Analysis

MedKoo Cat#: 561387
Name: VU0410150
CAS#: 1296731-74-2
Chemical Formula: C18H17N3O3S
Exact Mass: 355.10
Molecular Weight: 355.410
Elemental Analysis: C, 60.83; H, 4.82; N, 11.82; O, 13.50; S, 9.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VU0410150; VU 0410150; VU-0410150;

IUPAC/Chemical Name: N-(1-((3,4-Dimethylphenyl)sulfonyl)-1H-pyrrol-3-yl)picolinamide

InChi Key: LIVAPIWBIQYQLE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17N3O3S/c1-13-6-7-16(11-14(13)2)25(23,24)21-10-8-15(12-21)20-18(22)17-5-3-4-9-19-17/h3-12H,1-2H3,(H,20,22)

SMILES Code: O=C(NC1=CN(S(=O)(C2=CC=C(C)C(C)=C2)=O)C=C1)C3=NC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 355.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hopkins, C.R.; Lindsley, C.W.; Niswender, C.M. mGluR4-positive allosteric modulation as potential treatment for Parkinson’s disease. Future Med. Chem. 2009, 1, 501–513.

2: Gogliotti, R.D.; Blobaum, A.L.; Morrison, R.M.; Daniels, J.S.; Salovich, J.M.; Cheung, Y.Y.; Rodriguez, A.L.; Loch, M.T.; Conn, P.J.; Lindsley, C.W.; et al. Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). Bioorg. Med. Chem. Lett. 2016, 26, 2984–2987.